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Effects of some typical and atypical antidepressants on GAD activity in various brain regions

  • L. Rampello
  • , F. Patti
  • , F. Condorelli
  • , A. Reggio
  • , A. Prato
  • , P. L. Canonico
  • , F. Nicoletti

Research output: Contribution to journalArticlepeer-review

Abstract

The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalL'Encephale
Volume8
Issue number1
Publication statusPublished - 1982

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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