Effects of interferon alpha on murine cytomegalovirus replication.

M. G. Martinotti; G. Gribaudo; M. Gariglio; A. Angeretti; G. Cavallo; S. Landolfo

Effects of interferon alpha on murine cytomegalovirus replication.

M. G. Martinotti, G. Gribaudo, M. Gariglio, A. Angeretti, G. Cavallo, S. Landolfo

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Abstract

The present study examined the protective effect of IFN-alpha against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/HeJ) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-alpha was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-alpha pretreatment reduced the steady state level of immediate early and late mRNAs but partially reduced early gene expression.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Microbiologica
Volume	15
Issue number	2
Publication status	Published - Apr 1992
Externally published	Yes

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abstract = "The present study examined the protective effect of IFN-alpha against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/HeJ) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-alpha was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-alpha pretreatment reduced the steady state level of immediate early and late mRNAs but partially reduced early gene expression.",

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T1 - Effects of interferon alpha on murine cytomegalovirus replication.

AU - Martinotti, M. G.

AU - Gribaudo, G.

AU - Gariglio, M.

AU - Angeretti, A.

AU - Cavallo, G.

AU - Landolfo, S.

PY - 1992/4

Y1 - 1992/4

N2 - The present study examined the protective effect of IFN-alpha against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/HeJ) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-alpha was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-alpha pretreatment reduced the steady state level of immediate early and late mRNAs but partially reduced early gene expression.

AB - The present study examined the protective effect of IFN-alpha against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/HeJ) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-alpha was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-alpha pretreatment reduced the steady state level of immediate early and late mRNAs but partially reduced early gene expression.

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M3 - Article

SN - 0391-5352

VL - 15

SP - 183

EP - 186

JO - Microbiologica

JF - Microbiologica

IS - 2

ER -

Effects of interferon alpha on murine cytomegalovirus replication.

Abstract

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