Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Ferdinando Nicoletti; G. Dementi; A. Prato; P. L. Canonico; L. Rampello; F. Patti; R. M. Di Giorgio; U. Scapagnini

doi:10.1159/000123430

Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Ferdinando Nicoletti
, G. Dementi
, A. Prato
, P. L. Canonico
, L. Rampello
, F. Patti
, R. M. Di Giorgio
, U. Scapagnini

Research output: Contribution to journal › Article › peer-review

Abstract

Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

Original language	English
Pages (from-to)	13-16
Number of pages	4
Journal	Neuroendocrinology
Volume	36
Issue number	1
DOIs	https://doi.org/10.1159/000123430
Publication status	Published - 1983
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Glutamic acid decarboxylase
Medial basal hypothalamus
Prolactin

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10.1159/000123430

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title = "Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat",

abstract = "Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.",

keywords = "Glutamic acid decarboxylase, Medial basal hypothalamus, Prolactin",

author = "Ferdinando Nicoletti and G. Dementi and A. Prato and Canonico, \{P. L.\} and L. Rampello and F. Patti and \{Di Giorgio\}, \{R. M.\} and U. Scapagnini",

year = "1983",

doi = "10.1159/000123430",

language = "English",

volume = "36",

pages = "13--16",

journal = "Neuroendocrinology",

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TY - JOUR

T1 - Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

AU - Nicoletti, Ferdinando

AU - Dementi, G.

AU - Prato, A.

AU - Canonico, P. L.

AU - Rampello, L.

AU - Patti, F.

AU - Di Giorgio, R. M.

AU - Scapagnini, U.

PY - 1983

Y1 - 1983

N2 - Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

AB - Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

KW - Glutamic acid decarboxylase

KW - Medial basal hypothalamus

KW - Prolactin

UR - https://www.scopus.com/pages/publications/0020701316

U2 - 10.1159/000123430

DO - 10.1159/000123430

M3 - Article

SN - 0028-3835

VL - 36

SP - 13

EP - 16

JO - Neuroendocrinology

JF - Neuroendocrinology

IS - 1

ER -

Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Abstract

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Keywords

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