Effects of chronic ethanol treatment on α-MSH concentrations in rat brain and pituitary

I. Rainero; T. De Gennaro; G. Visentin; E. Brunetti; P. Cerrato; E. Torre; P. Portaleone; L. Pinessi

doi:10.1016/0143-4179(90)90145-O

Effects of chronic ethanol treatment on α-MSH concentrations in rat brain and pituitary

I. Rainero
, T. De Gennaro
, G. Visentin
, E. Brunetti
, P. Cerrato
, E. Torre
, P. Portaleone
, L. Pinessi

Research output: Contribution to journal › Article › peer-review

Abstract

Male Sprague-Dawley rats were chronically treated with a liquid diet containing 6.5% ( v v) ethanol or equicaloric sucrose. Rats were killed after 21 days of treatment. α-MSH-like immunoreactivity was measured in the intermediate lobe of the pituitary gland and in several brain regions. Chronic ethanol treatment significantly reduced α-MSH-like immunoreactivity in the pituitary gland; in the arcuate nucleus of the hypothalamus and in the substantia nigra. The results of this study confirm the earlier findings that chronic ethanol treatment reduces POMC biosynthesis in the pituitary gland and in the central nervous system.

Original language	English
Pages (from-to)	139-141
Number of pages	3
Journal	Neuropeptides
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/0143-4179(90)90145-O
Publication status	Published - Mar 1990
Externally published	Yes

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10.1016/0143-4179(90)90145-O

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title = "Effects of chronic ethanol treatment on α-MSH concentrations in rat brain and pituitary",

abstract = "Male Sprague-Dawley rats were chronically treated with a liquid diet containing 6.5\% ( v v) ethanol or equicaloric sucrose. Rats were killed after 21 days of treatment. α-MSH-like immunoreactivity was measured in the intermediate lobe of the pituitary gland and in several brain regions. Chronic ethanol treatment significantly reduced α-MSH-like immunoreactivity in the pituitary gland; in the arcuate nucleus of the hypothalamus and in the substantia nigra. The results of this study confirm the earlier findings that chronic ethanol treatment reduces POMC biosynthesis in the pituitary gland and in the central nervous system.",

author = "I. Rainero and \{De Gennaro\}, T. and G. Visentin and E. Brunetti and P. Cerrato and E. Torre and P. Portaleone and L. Pinessi",

year = "1990",

month = mar,

doi = "10.1016/0143-4179(90)90145-O",

language = "English",

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journal = "Neuropeptides",

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T1 - Effects of chronic ethanol treatment on α-MSH concentrations in rat brain and pituitary

AU - Rainero, I.

AU - De Gennaro, T.

AU - Visentin, G.

AU - Brunetti, E.

AU - Cerrato, P.

AU - Torre, E.

AU - Portaleone, P.

AU - Pinessi, L.

PY - 1990/3

Y1 - 1990/3

N2 - Male Sprague-Dawley rats were chronically treated with a liquid diet containing 6.5% ( v v) ethanol or equicaloric sucrose. Rats were killed after 21 days of treatment. α-MSH-like immunoreactivity was measured in the intermediate lobe of the pituitary gland and in several brain regions. Chronic ethanol treatment significantly reduced α-MSH-like immunoreactivity in the pituitary gland; in the arcuate nucleus of the hypothalamus and in the substantia nigra. The results of this study confirm the earlier findings that chronic ethanol treatment reduces POMC biosynthesis in the pituitary gland and in the central nervous system.

AB - Male Sprague-Dawley rats were chronically treated with a liquid diet containing 6.5% ( v v) ethanol or equicaloric sucrose. Rats were killed after 21 days of treatment. α-MSH-like immunoreactivity was measured in the intermediate lobe of the pituitary gland and in several brain regions. Chronic ethanol treatment significantly reduced α-MSH-like immunoreactivity in the pituitary gland; in the arcuate nucleus of the hypothalamus and in the substantia nigra. The results of this study confirm the earlier findings that chronic ethanol treatment reduces POMC biosynthesis in the pituitary gland and in the central nervous system.

UR - https://www.scopus.com/pages/publications/0025159282

U2 - 10.1016/0143-4179(90)90145-O

DO - 10.1016/0143-4179(90)90145-O

M3 - Article

SN - 0143-4179

VL - 15

SP - 139

EP - 141

JO - Neuropeptides

JF - Neuropeptides

IS - 3

ER -

Effects of chronic ethanol treatment on α-MSH concentrations in rat brain and pituitary

Abstract

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