Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice

Carmela Fiorito; Maria Luisa Balestrieri; Ettore Crimi; Alfonso Giovane; Vincenzo Grimaldi; Pellegrino Biagio Minucci; Luigi Servillo; Francesco Paolo D'Armiento; Bartolomeo Farzati; Claudio Napoli

doi:10.1016/j.ijcard.2007.12.004

Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice

Carmela Fiorito
, Maria Luisa Balestrieri
, Ettore Crimi
, Alfonso Giovane
, Vincenzo Grimaldi
, Pellegrino Biagio Minucci
, Luigi Servillo
, Francesco Paolo D'Armiento
, Bartolomeo Farzati
, Claudio Napoli

Research output: Contribution to journal › Article › peer-review

Abstract

Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.

Original language	English
Pages (from-to)	421-423
Number of pages	3
Journal	International Journal of Cardiology
Volume	126
Issue number	3
DOIs	https://doi.org/10.1016/j.ijcard.2007.12.004
Publication status	Published - 6 Jun 2008
Externally published	Yes

Keywords

Endothelial progenitor cells
Physical exercise
l-Arginine

Access to Document

10.1016/j.ijcard.2007.12.004

Cite this

@article{283923e303b847a48cd05ffcab469cfc,

title = "Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice",

abstract = "Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.",

keywords = "Endothelial progenitor cells, Physical exercise, l-Arginine",

author = "Carmela Fiorito and Balestrieri, \{Maria Luisa\} and Ettore Crimi and Alfonso Giovane and Vincenzo Grimaldi and Minucci, \{Pellegrino Biagio\} and Luigi Servillo and D'Armiento, \{Francesco Paolo\} and Bartolomeo Farzati and Claudio Napoli",

note = "Funding Information: This work was supported by PRIN MIUR 2006 code 0622153\_002 “Meccanismi fisiopatologici di danno vascolare/trombotico e angiogenesis” (C.N) and by Fondation Jerome Lejeune (C.N.).",

year = "2008",

month = jun,

day = "6",

doi = "10.1016/j.ijcard.2007.12.004",

language = "English",

volume = "126",

pages = "421--423",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice

AU - Fiorito, Carmela

AU - Balestrieri, Maria Luisa

AU - Crimi, Ettore

AU - Giovane, Alfonso

AU - Grimaldi, Vincenzo

AU - Minucci, Pellegrino Biagio

AU - Servillo, Luigi

AU - D'Armiento, Francesco Paolo

AU - Farzati, Bartolomeo

AU - Napoli, Claudio

N1 - Funding Information: This work was supported by PRIN MIUR 2006 code 0622153_002 “Meccanismi fisiopatologici di danno vascolare/trombotico e angiogenesis” (C.N) and by Fondation Jerome Lejeune (C.N.).

PY - 2008/6/6

Y1 - 2008/6/6

N2 - Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.

AB - Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.

KW - Endothelial progenitor cells

KW - Physical exercise

KW - l-Arginine

UR - https://www.scopus.com/pages/publications/43049176181

U2 - 10.1016/j.ijcard.2007.12.004

DO - 10.1016/j.ijcard.2007.12.004

M3 - Article

SN - 0167-5273

VL - 126

SP - 421

EP - 423

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 3

ER -

Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this