TY - JOUR
T1 - Effect of l-arginine on circulating endothelial progenitor cells and VEGF after moderate physical training in mice
AU - Fiorito, Carmela
AU - Balestrieri, Maria Luisa
AU - Crimi, Ettore
AU - Giovane, Alfonso
AU - Grimaldi, Vincenzo
AU - Minucci, Pellegrino Biagio
AU - Servillo, Luigi
AU - D'Armiento, Francesco Paolo
AU - Farzati, Bartolomeo
AU - Napoli, Claudio
N1 - Funding Information:
This work was supported by PRIN MIUR 2006 code 0622153_002 “Meccanismi fisiopatologici di danno vascolare/trombotico e angiogenesis” (C.N) and by Fondation Jerome Lejeune (C.N.).
PY - 2008/6/6
Y1 - 2008/6/6
N2 - Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.
AB - Alteration of levels and functional activities of circulating endothelial progenitor cells (EPCs) induced by risk factors for coronary heart disease (CHD) profoundly influence their role in the regeneration of tissue ischemia and angiogenesis. Among antioxidant nutrients in the prevention of CHD, l-arginine is particularly effective in enhancing the protection afforded by moderate physical exercise. Here, we aimed to evaluate the effects of l-arginine on EPC levels in C57BL/6J mice subjected to moderate physical exercise. Results showed that supplementation with l-arginine potentiates the effects of moderate physical exercise by increasing significantly EPCs (P < 0.001) and VEGF serum levels (P < 0.001). Our report highlights the beneficial effect of l-arginine in the modulation of EPC levels and VEGF secretion.
KW - Endothelial progenitor cells
KW - Physical exercise
KW - l-Arginine
UR - http://www.scopus.com/inward/record.url?scp=43049176181&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2007.12.004
DO - 10.1016/j.ijcard.2007.12.004
M3 - Article
SN - 0167-5273
VL - 126
SP - 421
EP - 423
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -