Effect of anti μ chain specific immunosuppression on Chikungunya virus encephalitis of mice

M. Giovarelli; I. Viano; M. Zucca; R. Valbonesi; F. Dianzanil

doi:10.1128/iai.16.3.849-852.1977

Effect of anti μ chain specific immunosuppression on Chikungunya virus encephalitis of mice

M. Giovarelli, I. Viano, M. Zucca, R. Valbonesi, F. Dianzanil

Research output: Contribution to journal › Article › peer-review

Abstract

Mice neonatally immunosuppressed with anti-μ antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.

Original language	English
Pages (from-to)	849-852
Number of pages	4
Journal	Unknown Journal
Volume	16
Issue number	3
DOIs	https://doi.org/10.1128/iai.16.3.849-852.1977
Publication status	Published - 1977
Externally published	Yes

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10.1128/iai.16.3.849-852.1977

Cite this

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title = "Effect of anti μ chain specific immunosuppression on Chikungunya virus encephalitis of mice",

abstract = "Mice neonatally immunosuppressed with anti-μ antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.",

author = "M. Giovarelli and I. Viano and M. Zucca and R. Valbonesi and F. Dianzanil",

year = "1977",

doi = "10.1128/iai.16.3.849-852.1977",

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pages = "849--852",

journal = "Unknown Journal",

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T1 - Effect of anti μ chain specific immunosuppression on Chikungunya virus encephalitis of mice

AU - Giovarelli, M.

AU - Viano, I.

AU - Zucca, M.

AU - Valbonesi, R.

AU - Dianzanil, F.

PY - 1977

Y1 - 1977

N2 - Mice neonatally immunosuppressed with anti-μ antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.

AB - Mice neonatally immunosuppressed with anti-μ antiserum failed to produce circulating antibodies to sheep erythrocytes and showed a marked decrease in circulating immunoglobulins. However, when they were intracerebrally infected with Chikungunya virus (a group A togavirus), they showed a mortality rate consistently lower than non-immunosuppressed control mice. Several possible explanations for this finding are discussed.

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U2 - 10.1128/iai.16.3.849-852.1977

DO - 10.1128/iai.16.3.849-852.1977

M3 - Article

VL - 16

SP - 849

EP - 852

JO - Unknown Journal

JF - Unknown Journal

IS - 3

ER -

Effect of anti μ chain specific immunosuppression on Chikungunya virus encephalitis of mice

Abstract

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