Doxorubicine englobed in polybutylcyanoacrylate nanocapsules: behaviour in vitro and in vivo

Nanocapsules of polybutylcyanoacrylate containing doxorubicine were prepared from w/o microemulsion. A concentration of about 10 % of the drug was obtained. After washing, dispersion and lyophilization of the nanocapsules, some experiments were performed in vivo and in vitro. About 1 % of doxorubicine was released in vitro in 48 hours; after injection on the hairless back of rabbits, the nanoparticles without the drug gave any inflammatory processes, while the nanocapsules containing doxorubicine gave a deeper and more prolonged ulcer than that of the same amount of doxorubicine in solution, indicating that practically all the drug was inside the nanocapsules.