Differential integrin expression in thyroid and laryngeal carcinomas

Carlevato MT; L Trusolino; G Serini; Guido VALENTE; F Orlandi; A Angeli; G Cortesina; Marchisio PC

Differential integrin expression in thyroid and laryngeal carcinomas

Carlevato MT
, L Trusolino
, G Serini
, Guido VALENTE
, F Orlandi
, A Angeli
, G Cortesina
, Marchisio PC

Department of Translational Medicine

Research output: Contribution to journal › Article

Abstract

Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

Original language	English
Pages (from-to)	2379-2384
Number of pages	6
Journal	Anticancer Research
Volume	16
Issue number	4C
Publication status	Published - 1996

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title = "Differential integrin expression in thyroid and laryngeal carcinomas",

abstract = "Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.",

author = "Carlevato MT and L Trusolino and G Serini and Guido VALENTE and F Orlandi and A Angeli and G Cortesina and Marchisio PC",

year = "1996",

language = "English",

volume = "16",

pages = "2379--2384",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "4C",

}

TY - JOUR

T1 - Differential integrin expression in thyroid and laryngeal carcinomas

AU - MT, Carlevato

AU - Trusolino, L

AU - Serini, G

AU - VALENTE, Guido

AU - Orlandi, F

AU - Angeli, A

AU - Cortesina, G

AU - PC, Marchisio

PY - 1996

Y1 - 1996

N2 - Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

AB - Several laryngeal and thyroid carcinomas were studied immunohistochemically to evaluate whether the expression and distribution of integrins and basal lamina components can represent reproducible markers for correct diagnosis and prognosis. In laryngeal cancers, the depolarization and pericellular redistribution of α3β1 and α6β4, and focal or fragmentation of the basal lamina, according to tumor prognosis, occurred. In thyroid carcinomas, loss of polar topography of α3β1 and neo-expression of α6β4 in histopathologically or clinically aggressive cancers were observed. Therefore, the addition of a panel of adhesion molecules to the toolbox of surgical pathologists may improve diagnostic and prognostic procedures.

UR - https://iris.uniupo.it/handle/11579/4862

M3 - Article

SN - 0250-7005

VL - 16

SP - 2379

EP - 2384

JO - Anticancer Research

JF - Anticancer Research

IS - 4C

ER -

Differential integrin expression in thyroid and laryngeal carcinomas

Abstract

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