Differential actions of neurotrophic factors on lesion-induced damage of the serotonergic neurons projecting to the hippocampus

Grazia Lombardi; Massimo Beni; Vincenzo Carla; Gino Toffano; Flavio Moroni

doi:10.1016/0006-8993(88)90477-5

Differential actions of neurotrophic factors on lesion-induced damage of the serotonergic neurons projecting to the hippocampus

Grazia Lombardi
, Massimo Beni
, Vincenzo Carla
, Gino Toffano
, Flavio Moroni

Research output: Contribution to journal › Article › peer-review

Abstract

The changes induced by nerve growth factor (NGF) and by GM₁-ganglioside administration on serotonin (5-HT), 5-hydroxyin-doleacetic acid (5-HIAA) and tryptophan content and on choline acetyltransferase activity, were studied in the central nervous system of rats undergoing electrolytic damage of a mesencephalic area, located near the nucleus interpeduncularis. This lesion selectively reduced the content of 5-HT and 5-HIAA in the ipsilateral hippocampus. Daily intraperitoneal injection of GM₁-ganglioside (30 mg/kg/day for 6-14 days) significantly reduced the injury-induced loss of hippocampal 5-HT and 5-HIAA content. On the contrary NGF, administered at a dose (10 μg/rat i.c.v. twice a week for 2 weeks) which was able to increase, in the same animals, the cortical choline acetyltransferase activity, failed to affect the lesion-induced reduction of 5-HT and of 5-HIAA in the hippocampus.

Original language	English
Pages (from-to)	348-352
Number of pages	5
Journal	Brain Research
Volume	458
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(88)90477-5
Publication status	Published - 23 Aug 1988
Externally published	Yes

Keywords

Choline acetyltransferase
Ganglioside
Hippocampal serotonin
Nerve growth factor

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10.1016/0006-8993(88)90477-5

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title = "Differential actions of neurotrophic factors on lesion-induced damage of the serotonergic neurons projecting to the hippocampus",

abstract = "The changes induced by nerve growth factor (NGF) and by GM1-ganglioside administration on serotonin (5-HT), 5-hydroxyin-doleacetic acid (5-HIAA) and tryptophan content and on choline acetyltransferase activity, were studied in the central nervous system of rats undergoing electrolytic damage of a mesencephalic area, located near the nucleus interpeduncularis. This lesion selectively reduced the content of 5-HT and 5-HIAA in the ipsilateral hippocampus. Daily intraperitoneal injection of GM1-ganglioside (30 mg/kg/day for 6-14 days) significantly reduced the injury-induced loss of hippocampal 5-HT and 5-HIAA content. On the contrary NGF, administered at a dose (10 μg/rat i.c.v. twice a week for 2 weeks) which was able to increase, in the same animals, the cortical choline acetyltransferase activity, failed to affect the lesion-induced reduction of 5-HT and of 5-HIAA in the hippocampus.",

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author = "Grazia Lombardi and Massimo Beni and Vincenzo Carla and Gino Toffano and Flavio Moroni",

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AU - Lombardi, Grazia

AU - Beni, Massimo

AU - Carla, Vincenzo

AU - Toffano, Gino

AU - Moroni, Flavio

PY - 1988/8/23

Y1 - 1988/8/23

N2 - The changes induced by nerve growth factor (NGF) and by GM1-ganglioside administration on serotonin (5-HT), 5-hydroxyin-doleacetic acid (5-HIAA) and tryptophan content and on choline acetyltransferase activity, were studied in the central nervous system of rats undergoing electrolytic damage of a mesencephalic area, located near the nucleus interpeduncularis. This lesion selectively reduced the content of 5-HT and 5-HIAA in the ipsilateral hippocampus. Daily intraperitoneal injection of GM1-ganglioside (30 mg/kg/day for 6-14 days) significantly reduced the injury-induced loss of hippocampal 5-HT and 5-HIAA content. On the contrary NGF, administered at a dose (10 μg/rat i.c.v. twice a week for 2 weeks) which was able to increase, in the same animals, the cortical choline acetyltransferase activity, failed to affect the lesion-induced reduction of 5-HT and of 5-HIAA in the hippocampus.

AB - The changes induced by nerve growth factor (NGF) and by GM1-ganglioside administration on serotonin (5-HT), 5-hydroxyin-doleacetic acid (5-HIAA) and tryptophan content and on choline acetyltransferase activity, were studied in the central nervous system of rats undergoing electrolytic damage of a mesencephalic area, located near the nucleus interpeduncularis. This lesion selectively reduced the content of 5-HT and 5-HIAA in the ipsilateral hippocampus. Daily intraperitoneal injection of GM1-ganglioside (30 mg/kg/day for 6-14 days) significantly reduced the injury-induced loss of hippocampal 5-HT and 5-HIAA content. On the contrary NGF, administered at a dose (10 μg/rat i.c.v. twice a week for 2 weeks) which was able to increase, in the same animals, the cortical choline acetyltransferase activity, failed to affect the lesion-induced reduction of 5-HT and of 5-HIAA in the hippocampus.

KW - Choline acetyltransferase

KW - Ganglioside

KW - Hippocampal serotonin

KW - Nerve growth factor

UR - https://www.scopus.com/pages/publications/0023687069

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DO - 10.1016/0006-8993(88)90477-5

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SP - 348

EP - 352

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Differential actions of neurotrophic factors on lesion-induced damage of the serotonergic neurons projecting to the hippocampus

Abstract

Keywords

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