Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Clara Cena; Donatella Boschi; Gian Cesare Tron; Kostantin Chegaev; Loretta Lazzarato; Antonella Di Stilo; Manuela Aragno; Roberta Fruttero; Alberto Gasco

doi:10.1016/j.bmcl.2004.10.006

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Clara Cena
, Donatella Boschi
, Gian Cesare Tron
, Kostantin Chegaev
, Loretta Lazzarato
, Antonella Di Stilo
, Manuela Aragno
, Roberta Fruttero
, Alberto Gasco

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

Original language	English
Pages (from-to)	5971-5974
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	14
Issue number	24
DOIs	https://doi.org/10.1016/j.bmcl.2004.10.006
Publication status	Published - 20 Dec 2004

Keywords

NO donors
NO-donor phenol antioxidants
Nitric oxide
Phenol antioxidants

Access to Document

10.1016/j.bmcl.2004.10.006

Cite this

@article{372c58e4b7d144bc93a5c0370f541509,

title = "Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants",

abstract = "A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.",

keywords = "NO donors, NO-donor phenol antioxidants, Nitric oxide, Phenol antioxidants",

author = "Clara Cena and Donatella Boschi and Tron, \{Gian Cesare\} and Kostantin Chegaev and Loretta Lazzarato and Stilo, \{Antonella Di\} and Manuela Aragno and Roberta Fruttero and Alberto Gasco",

note = "Funding Information: This study was supported by a MIUR grant.",

year = "2004",

month = dec,

day = "20",

doi = "10.1016/j.bmcl.2004.10.006",

language = "English",

volume = "14",

pages = "5971--5974",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

number = "24",

}

TY - JOUR

T1 - Development of a new class of potential antiatherosclerosis agents

T2 - NO-donor antioxidants

AU - Cena, Clara

AU - Boschi, Donatella

AU - Tron, Gian Cesare

AU - Chegaev, Kostantin

AU - Lazzarato, Loretta

AU - Stilo, Antonella Di

AU - Aragno, Manuela

AU - Fruttero, Roberta

AU - Gasco, Alberto

N1 - Funding Information: This study was supported by a MIUR grant.

PY - 2004/12/20

Y1 - 2004/12/20

N2 - A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

AB - A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine. A new class of NO-donor phenol derivatives is described. The products were obtained by joining appropriate phenols with either nitrooxy or 3-phenylsulfonylfuroxan-4-yloxy moieties. All the compounds proved to inhibit the ferrous salt/ascorbate induced lipidic peroxidation of membrane lipids of rat hepatocytes. They were also capable of dilating rat aorta strips precontracted with phenylephrine.

KW - NO donors

KW - NO-donor phenol antioxidants

KW - Nitric oxide

KW - Phenol antioxidants

UR - https://www.scopus.com/pages/publications/8844265397

U2 - 10.1016/j.bmcl.2004.10.006

DO - 10.1016/j.bmcl.2004.10.006

M3 - Article

SN - 0960-894X

VL - 14

SP - 5971

EP - 5974

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 24

ER -

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this