Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Paola Maria Manzini; Giovannino Ciccone; Francesco Giuseppe De Rosa; Rossana Cavallo; Valeria Ghisetti; Sergio D'Antico; Claudia Galassi; Fabio Saccona; Anna Castiglione; Nadia Birocco; Tiziana Francisci; Huijing Hu; Clara Pecoraro; Franca Danielle; Luciana Labanca; Anna Maria Bordiga; Marco Lorenzi; Giovanni Camisasca; Osvaldo Giachino; Mauro Pagliarino; Piero Ottone; Ilvana Tiziana Donatella Scuvera; Roberto Guaschino; Roberto Freilone; Pierluigi Berti; Fabrizia Pittaluga; Maria Avolio; Cristina Costa; Samuele Raso; Aurora Nucci; Massimo Milan; Alessandra Baffa; Alessandra Russo; Antonella Tornello; Laura Maddalena; Grazia Delios; Fabio Paolo Marletto; Anna Grazia De Micheli; Alessio Mattei; Stefano Baldassano; Francesca Canta; Maria Luisa Russo; Daniele Bergamo; Francesco Vitale; Marco Maria Liccardi; Alessandra Chinaglia; Andrea CALCAGNO; Marcella Converso; Chiara Aldieri; Valentina Libanore; Ilaria Blangetti; Valentina Benedetti; Barbara Mitola; Gitana Scozzari; Brazzi l

doi:10.1186/s12879-022-07716-5

Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Paola Maria Manzini
, Giovannino Ciccone
, Francesco Giuseppe De Rosa
, Rossana Cavallo
, Valeria Ghisetti
, Sergio D'Antico
, Claudia Galassi
, Fabio Saccona
, Anna Castiglione
, Nadia Birocco
, Tiziana Francisci
, Huijing Hu
, Clara Pecoraro
, Franca Danielle
, Luciana Labanca
, Anna Maria Bordiga
, Marco Lorenzi
, Giovanni Camisasca
, Osvaldo Giachino
, Mauro Pagliarino

Piero Ottone, Ilvana Tiziana Donatella Scuvera, Roberto Guaschino, Roberto Freilone, Pierluigi Berti, Fabrizia Pittaluga, Maria Avolio, Cristina Costa, Samuele Raso, Aurora Nucci, Massimo Milan, Alessandra Baffa, Alessandra Russo, Antonella Tornello, Laura Maddalena, Grazia Delios, Fabio Paolo Marletto, Anna Grazia De Micheli, Alessio Mattei, Stefano Baldassano, Francesca Canta, Maria Luisa Russo, Daniele Bergamo, Francesco Vitale, Marco Maria Liccardi, Alessandra Chinaglia, Andrea CALCAGNO, Marcella Converso, Chiara Aldieri, Valentina Libanore, Ilaria Blangetti, Valentina Benedetti, Barbara Mitola, Gitana Scozzari, Brazzi l

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies.

Original language	English
Pages (from-to)	879-892
Number of pages	14
Journal	BMC Infectious Diseases
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12879-022-07716-5
Publication status	Published - 2022

Keywords

COVID-19 convalescent plasma
COVID-19 outcomes
COVID-19 therapy
Randomized clinical trial
Adult
Male
Humans
Aged
Female
Standard of Care
Plasma
COVID-19
Respiratory Insufficiency

Access to Document

10.1186/s12879-022-07716-5

https://hdl.handle.net/11579/217034

Cite this

Manzini, P. M., Ciccone, G., De Rosa, F. G., Cavallo, R., Ghisetti, V., D'Antico, S., Galassi, C., Saccona, F., Castiglione, A., Birocco, N., Francisci, T., Hu, H., Pecoraro, C., Danielle, F., Labanca, L., Bordiga, A. M., Lorenzi, M., Camisasca, G., Giachino, O., ... l, B. (2022). Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial. BMC Infectious Diseases, 22(1), 879-892. https://doi.org/10.1186/s12879-022-07716-5

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title = "Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial",

abstract = "The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies.",

keywords = "COVID-19 convalescent plasma, COVID-19 outcomes, COVID-19 therapy, Randomized clinical trial, Adult, Male, Humans, Aged, Female, Standard of Care, Plasma, COVID-19, Respiratory Insufficiency, COVID-19 convalescent plasma, COVID-19 outcomes, COVID-19 therapy, Randomized clinical trial, Adult, Male, Humans, Aged, Female, Standard of Care, Plasma, COVID-19, Respiratory Insufficiency",

author = "Manzini, \{Paola Maria\} and Giovannino Ciccone and \{De Rosa\}, \{Francesco Giuseppe\} and Rossana Cavallo and Valeria Ghisetti and Sergio D'Antico and Claudia Galassi and Fabio Saccona and Anna Castiglione and Nadia Birocco and Tiziana Francisci and Huijing Hu and Clara Pecoraro and Franca Danielle and Luciana Labanca and Bordiga, \{Anna Maria\} and Marco Lorenzi and Giovanni Camisasca and Osvaldo Giachino and Mauro Pagliarino and Piero Ottone and Scuvera, \{Ilvana Tiziana Donatella\} and Roberto Guaschino and Roberto Freilone and Pierluigi Berti and Fabrizia Pittaluga and Maria Avolio and Cristina Costa and Samuele Raso and Aurora Nucci and Massimo Milan and Alessandra Baffa and Alessandra Russo and Antonella Tornello and Laura Maddalena and Grazia Delios and Marletto, \{Fabio Paolo\} and \{De Micheli\}, \{Anna Grazia\} and Alessio Mattei and Stefano Baldassano and Francesca Canta and Russo, \{Maria Luisa\} and Daniele Bergamo and Francesco Vitale and Liccardi, \{Marco Maria\} and Alessandra Chinaglia and Andrea CALCAGNO and Marcella Converso and Chiara Aldieri and Valentina Libanore and Ilaria Blangetti and Valentina Benedetti and Barbara Mitola and Gitana Scozzari and Brazzi l",

year = "2022",

doi = "10.1186/s12879-022-07716-5",

language = "English",

volume = "22",

pages = "879--892",

journal = "BMC Infectious Diseases",

issn = "1471-2334",

publisher = "BioMed Central Ltd.",

number = "1",

}

Manzini, PM, Ciccone, G, De Rosa, FG, Cavallo, R, Ghisetti, V, D'Antico, S, Galassi, C, Saccona, F, Castiglione, A, Birocco, N, Francisci, T, Hu, H, Pecoraro, C, Danielle, F, Labanca, L, Bordiga, AM, Lorenzi, M, Camisasca, G, Giachino, O, Pagliarino, M, Ottone, P, Scuvera, ITD, Guaschino, R, Freilone, R, Berti, P, Pittaluga, F, Avolio, M, Costa, C, Raso, S, Nucci, A, Milan, M, Baffa, A, Russo, A, Tornello, A, Maddalena, L, Delios, G, Marletto, FP, De Micheli, AG, Mattei, A, Baldassano, S, Canta, F, Russo, ML, Bergamo, D, Vitale, F, Liccardi, MM, Chinaglia, A, CALCAGNO, A, Converso, M, Aldieri, C, Libanore, V, Blangetti, I, Benedetti, V, Mitola, B, Scozzari, G & l, B 2022, 'Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial', BMC Infectious Diseases, vol. 22, no. 1, pp. 879-892. https://doi.org/10.1186/s12879-022-07716-5

Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial. / Manzini, Paola Maria; Ciccone, Giovannino; De Rosa, Francesco Giuseppe et al.
In: BMC Infectious Diseases, Vol. 22, No. 1, 2022, p. 879-892.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

AU - Manzini, Paola Maria

AU - Ciccone, Giovannino

AU - De Rosa, Francesco Giuseppe

AU - Cavallo, Rossana

AU - Ghisetti, Valeria

AU - D'Antico, Sergio

AU - Galassi, Claudia

AU - Saccona, Fabio

AU - Castiglione, Anna

AU - Birocco, Nadia

AU - Francisci, Tiziana

AU - Hu, Huijing

AU - Pecoraro, Clara

AU - Danielle, Franca

AU - Labanca, Luciana

AU - Bordiga, Anna Maria

AU - Lorenzi, Marco

AU - Camisasca, Giovanni

AU - Giachino, Osvaldo

AU - Pagliarino, Mauro

AU - Ottone, Piero

AU - Scuvera, Ilvana Tiziana Donatella

AU - Guaschino, Roberto

AU - Freilone, Roberto

AU - Berti, Pierluigi

AU - Pittaluga, Fabrizia

AU - Avolio, Maria

AU - Costa, Cristina

AU - Raso, Samuele

AU - Nucci, Aurora

AU - Milan, Massimo

AU - Baffa, Alessandra

AU - Russo, Alessandra

AU - Tornello, Antonella

AU - Maddalena, Laura

AU - Delios, Grazia

AU - Marletto, Fabio Paolo

AU - De Micheli, Anna Grazia

AU - Mattei, Alessio

AU - Baldassano, Stefano

AU - Canta, Francesca

AU - Russo, Maria Luisa

AU - Bergamo, Daniele

AU - Vitale, Francesco

AU - Liccardi, Marco Maria

AU - Chinaglia, Alessandra

AU - CALCAGNO, Andrea

AU - Converso, Marcella

AU - Aldieri, Chiara

AU - Libanore, Valentina

AU - Blangetti, Ilaria

AU - Benedetti, Valentina

AU - Mitola, Barbara

AU - Scozzari, Gitana

AU - l, Brazzi

PY - 2022

Y1 - 2022

N2 - The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies.

AB - The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies.

KW - COVID-19 convalescent plasma

KW - COVID-19 outcomes

KW - COVID-19 therapy

KW - Randomized clinical trial

KW - Adult

KW - Male

KW - Humans

KW - Aged

KW - Female

KW - Standard of Care

KW - Plasma

KW - COVID-19

KW - Respiratory Insufficiency

KW - COVID-19 convalescent plasma

KW - COVID-19 outcomes

KW - COVID-19 therapy

KW - Randomized clinical trial

KW - Adult

KW - Male

KW - Humans

KW - Aged

KW - Female

KW - Standard of Care

KW - Plasma

KW - COVID-19

KW - Respiratory Insufficiency

UR - https://iris.uniupo.it/handle/11579/217034

U2 - 10.1186/s12879-022-07716-5

DO - 10.1186/s12879-022-07716-5

M3 - Article

SN - 1471-2334

VL - 22

SP - 879

EP - 892

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

IS - 1

ER -

Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial

Abstract

Keywords

Access to Document

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