Contemporary issues on clopidogrel therapy

Giuseppe Patti, Germano Di Sciascio

Research output: Contribution to journalReview articlepeer-review

Abstract

In this paper, data from available studies regarding some contemporary issues on clopidogrel therapy are analyzed. In particular, the following clinical questions have been considered and addressed: (a) Is early clopidogrel treatment needed in patients with acute coronary syndromes treated medically or undergoing percutaneous coronary intervention (PCI)? (b) What is the optimal clopidogrel loading dose in patients undergoing PCI? (c) Is pre-treatment with clopidogrel before PCI needed, or can clopidogrel loading be given in the catheter laboratory before intervention, but after coronary anatomy is known? (d) What is the optimal clopidogrel strategy in patients on chronic clopidogrel therapy undergoing PCI? (e) Does the degree of clopidogrel response influence clinical outcome in patients undergoing PCI?

Original languageEnglish
Pages (from-to)201-211
Number of pages11
JournalInternal and Emergency Medicine
Volume4
Issue number3
DOIs
Publication statusPublished - Jun 2009
Externally publishedYes

Keywords

  • Acute coronary syndromes
  • Clopidogrel
  • Outcome
  • Percutaneous coronary intervention

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