Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

Tommaso Cai; Daniele Tiscione; Paolo Verze; Giorgio Pomara; Marco Racioppi; Gabriella Nesi; Mattia Barbareschi; Maurizio Brausi; Mauro Gacci; Lorenzo Giuseppe Luciani; Giovanni Liguori; Paolo Gontero; Fabio Campodonico; Alchiede Simonato; Vieri Boddi; Savino M. Di Stasi; Renzo Colombo; Vincenzo Serretta; Giorgio Carmignani; Gianni Malossini; Vincenzo Altieri; Marco Carini; Carlo Terrone; Pierfrancesco Bassi; Francesco Montorsi; Vincenzo Ficarra; Cesare Selli; Vincenzo Mirone; Riccardo Bartoletti

doi:10.1016/j.urology.2014.06.032

Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

Tommaso Cai
, Daniele Tiscione
, Paolo Verze
, Giorgio Pomara
, Marco Racioppi
, Gabriella Nesi
, Mattia Barbareschi
, Maurizio Brausi
, Mauro Gacci
, Lorenzo Giuseppe Luciani
, Giovanni Liguori
, Paolo Gontero
, Fabio Campodonico
, Alchiede Simonato
, Vieri Boddi
, Savino M. Di Stasi
, Renzo Colombo
, Vincenzo Serretta
, Giorgio Carmignani
, Gianni Malossini

Vincenzo Altieri, Marco Carini, Carlo Terrone, Pierfrancesco Bassi, Francesco Montorsi, Vincenzo Ficarra, Cesare Selli, Vincenzo Mirone, Riccardo Bartoletti

Research output: Contribution to journal › Article › peer-review

Abstract

Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.

Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.

Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P <.001). The presence of uncommon variants at TURBT was associated with an increased risk of pathologic upstage (hazard ratio, 3.24; confidence interval, 1.19-6.37; P <.003) and significant decrease in cancer-specific survival and recurrence-free survival (P <.001).

Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.

Original language	English
Pages (from-to)	1141-1146
Number of pages	6
Journal	Urology
Volume	84
Issue number	5
DOIs	https://doi.org/10.1016/j.urology.2014.06.032
Publication status	Published - 1 Nov 2014
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1016/j.urology.2014.06.032

Cite this

Cai, T., Tiscione, D., Verze, P., Pomara, G., Racioppi, M., Nesi, G., Barbareschi, M., Brausi, M., Gacci, M., Luciani, L. G., Liguori, G., Gontero, P., Campodonico, F., Simonato, A., Boddi, V., Di Stasi, S. M., Colombo, R., Serretta, V., Carmignani, G., ... Bartoletti, R. (2014). Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens. Urology, 84(5), 1141-1146. https://doi.org/10.1016/j.urology.2014.06.032

@article{a87cc15e5bb5463089fc53da1c182f7b,

title = "Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens",

abstract = "Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1\%), whereas 266 (6.4\%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P <.001). The presence of uncommon variants at TURBT was associated with an increased risk of pathologic upstage (hazard ratio, 3.24; confidence interval, 1.19-6.37; P <.003) and significant decrease in cancer-specific survival and recurrence-free survival (P <.001).Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.",

author = "Tommaso Cai and Daniele Tiscione and Paolo Verze and Giorgio Pomara and Marco Racioppi and Gabriella Nesi and Mattia Barbareschi and Maurizio Brausi and Mauro Gacci and Luciani, \{Lorenzo Giuseppe\} and Giovanni Liguori and Paolo Gontero and Fabio Campodonico and Alchiede Simonato and Vieri Boddi and \{Di Stasi\}, \{Savino M.\} and Renzo Colombo and Vincenzo Serretta and Giorgio Carmignani and Gianni Malossini and Vincenzo Altieri and Marco Carini and Carlo Terrone and Pierfrancesco Bassi and Francesco Montorsi and Vincenzo Ficarra and Cesare Selli and Vincenzo Mirone and Riccardo Bartoletti",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier Inc.",

year = "2014",

month = nov,

day = "1",

doi = "10.1016/j.urology.2014.06.032",

language = "English",

volume = "84",

pages = "1141--1146",

journal = "Urology",

issn = "0090-4295",

publisher = "Elsevier Inc.",

number = "5",

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Cai, T, Tiscione, D, Verze, P, Pomara, G, Racioppi, M, Nesi, G, Barbareschi, M, Brausi, M, Gacci, M, Luciani, LG, Liguori, G, Gontero, P, Campodonico, F, Simonato, A, Boddi, V, Di Stasi, SM, Colombo, R, Serretta, V, Carmignani, G, Malossini, G, Altieri, V, Carini, M, Terrone, C, Bassi, P, Montorsi, F, Ficarra, V, Selli, C, Mirone, V & Bartoletti, R 2014, 'Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens', Urology, vol. 84, no. 5, pp. 1141-1146. https://doi.org/10.1016/j.urology.2014.06.032

TY - JOUR

T1 - Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

AU - Cai, Tommaso

AU - Tiscione, Daniele

AU - Verze, Paolo

AU - Pomara, Giorgio

AU - Racioppi, Marco

AU - Nesi, Gabriella

AU - Barbareschi, Mattia

AU - Brausi, Maurizio

AU - Gacci, Mauro

AU - Luciani, Lorenzo Giuseppe

AU - Liguori, Giovanni

AU - Gontero, Paolo

AU - Campodonico, Fabio

AU - Simonato, Alchiede

AU - Boddi, Vieri

AU - Di Stasi, Savino M.

AU - Colombo, Renzo

AU - Serretta, Vincenzo

AU - Carmignani, Giorgio

AU - Malossini, Gianni

AU - Altieri, Vincenzo

AU - Carini, Marco

AU - Terrone, Carlo

AU - Bassi, Pierfrancesco

AU - Montorsi, Francesco

AU - Ficarra, Vincenzo

AU - Selli, Cesare

AU - Mirone, Vincenzo

AU - Bartoletti, Riccardo

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P <.001). The presence of uncommon variants at TURBT was associated with an increased risk of pathologic upstage (hazard ratio, 3.24; confidence interval, 1.19-6.37; P <.003) and significant decrease in cancer-specific survival and recurrence-free survival (P <.001).Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.

AB - Objective To evaluate the concordance and prognostic role of histologic variants of bladder urothelial carcinoma in transurethral resection of bladder tumor (TURBT) and radical cystectomy (RC) specimens.Methods Clinicopathologic information available at the time of RC and follow-up data from 4110 RC specimens, collected between January 2000 and December 2009 at 17 tertiary referral centers were retrospectively analyzed and evaluated for the presence or absence of uncommon variants of bladder urothelial carcinoma. The presence or absence of uncommon variants of bladder urothelial carcinoma was evaluated on previous TURBT specimens of patients undergoing RC. Cox regression was used to assess the impact of these parameters on cancer-specific survival, and the Kaplan-Meier test for disease-free survival was plotted for survival estimate.Results Of 4110 patients, 579 were found to have uncommon variants of bladder urothelial carcinoma at RC (14.1%), whereas 266 (6.4%) at TURBT. A lack of agreement about uncommon variants was observed between TURBT and RC specimens in the entire population (P <.001). The presence of uncommon variants at TURBT was associated with an increased risk of pathologic upstage (hazard ratio, 3.24; confidence interval, 1.19-6.37; P <.003) and significant decrease in cancer-specific survival and recurrence-free survival (P <.001).Conclusion Although the concordance of presence of uncommon histologic variants of urothelial bladder carcinoma between TURBT and RC is low, the presence of uncommon histologic variants of urothelial bladder carcinoma at TURBT is associated with a less favorable clinical outcome.

UR - https://www.scopus.com/pages/publications/84908333796

U2 - 10.1016/j.urology.2014.06.032

DO - 10.1016/j.urology.2014.06.032

M3 - Article

SN - 0090-4295

VL - 84

SP - 1141

EP - 1146

JO - Urology

JF - Urology

IS - 5

ER -

Concordance and clinical significance of uncommon variants of bladder urothelial carcinoma in transurethral resection and radical cystectomy specimens

Abstract

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