Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Dalemari Crowther-Swanepoel; Maria Chiara Di Bernardo; Krzysztof Jamroziak; Lidia Karabon; Irena Frydecka; Silvia Deaglio; Giovanni D'Arena; Davide Rossi; Gianluca Gaidano; Bianca Olver; Amy Lloyd; Peter Broderick; Luca Laurenti; Zofia Szemraj-Rogucka; Tadeusz Robak; Daniel Catovsky; Richard S. Houlston

doi:10.1111/j.1365-2141.2011.08706.x

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

Dalemari Crowther-Swanepoel
, Maria Chiara Di Bernardo
, Krzysztof Jamroziak
, Lidia Karabon
, Irena Frydecka
, Silvia Deaglio
, Giovanni D'Arena
, Davide Rossi
, Gianluca Gaidano
, Bianca Olver
, Amy Lloyd
, Peter Broderick
, Luca Laurenti
, Zofia Szemraj-Rogucka
, Tadeusz Robak
, Daniel Catovsky
, Richard S. Houlston

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (P_combined=1·10×10^-7 and 1·30×10^-5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

Original language	English
Pages (from-to)	229-233
Number of pages	5
Journal	British Journal of Haematology
Volume	154
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.2011.08706.x
Publication status	Published - Jul 2011

Keywords

CPEB1
Chronic lymphocytic leukaemia
Common variant
Risk

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10.1111/j.1365-2141.2011.08706.x

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Crowther-Swanepoel, D., Di Bernardo, M. C., Jamroziak, K., Karabon, L., Frydecka, I., Deaglio, S., D'Arena, G., Rossi, D., Gaidano, G., Olver, B., Lloyd, A., Broderick, P., Laurenti, L., Szemraj-Rogucka, Z., Robak, T., Catovsky, D., & Houlston, R. S. (2011). Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk. British Journal of Haematology, 154(2), 229-233. https://doi.org/10.1111/j.1365-2141.2011.08706.x

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title = "Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk",

abstract = "A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined=1·10×10-7 and 1·30×10-5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.",

keywords = "CPEB1, Chronic lymphocytic leukaemia, Common variant, Risk",

author = "Dalemari Crowther-Swanepoel and \{Di Bernardo\}, \{Maria Chiara\} and Krzysztof Jamroziak and Lidia Karabon and Irena Frydecka and Silvia Deaglio and Giovanni D'Arena and Davide Rossi and Gianluca Gaidano and Bianca Olver and Amy Lloyd and Peter Broderick and Luca Laurenti and Zofia Szemraj-Rogucka and Tadeusz Robak and Daniel Catovsky and Houlston, \{Richard S.\}",

year = "2011",

month = jul,

doi = "10.1111/j.1365-2141.2011.08706.x",

language = "English",

volume = "154",

pages = "229--233",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "John Wiley and Sons Inc.",

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Crowther-Swanepoel, D, Di Bernardo, MC, Jamroziak, K, Karabon, L, Frydecka, I, Deaglio, S, D'Arena, G, Rossi, D, Gaidano, G, Olver, B, Lloyd, A, Broderick, P, Laurenti, L, Szemraj-Rogucka, Z, Robak, T, Catovsky, D & Houlston, RS 2011, 'Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk', British Journal of Haematology, vol. 154, no. 2, pp. 229-233. https://doi.org/10.1111/j.1365-2141.2011.08706.x

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T1 - Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

AU - Crowther-Swanepoel, Dalemari

AU - Di Bernardo, Maria Chiara

AU - Jamroziak, Krzysztof

AU - Karabon, Lidia

AU - Frydecka, Irena

AU - Deaglio, Silvia

AU - D'Arena, Giovanni

AU - Rossi, Davide

AU - Gaidano, Gianluca

AU - Olver, Bianca

AU - Lloyd, Amy

AU - Broderick, Peter

AU - Laurenti, Luca

AU - Szemraj-Rogucka, Zofia

AU - Robak, Tadeusz

AU - Catovsky, Daniel

AU - Houlston, Richard S.

PY - 2011/7

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N2 - A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined=1·10×10-7 and 1·30×10-5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

AB - A genome-wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case-control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined=1·10×10-7 and 1·30×10-5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.

KW - CPEB1

KW - Chronic lymphocytic leukaemia

KW - Common variant

KW - Risk

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DO - 10.1111/j.1365-2141.2011.08706.x

M3 - Article

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VL - 154

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EP - 233

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -

Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk

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Keywords

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