Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

Mauro Ravera; Elisabetta Gabano; Ilaria Zanellato; Beatrice Rangone; Elena Perin; Beatrice Ferrari; Maria Grazia Bottone; Domenico Osella

doi:10.1039/d0dt04051g

Cis,cis,trans-[Pt^IVCl₂(NH₃)₂(perillato)₂], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

Mauro Ravera
, Elisabetta Gabano
, Ilaria Zanellato
, Beatrice Rangone
, Elena Perin
, Beatrice Ferrari
, Maria Grazia Bottone
, Domenico Osella

Research output: Contribution to journal › Article › peer-review

Abstract

Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[Pt^IVCl₂(NH₃)₂(perillato)₂] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.

Original language	English
Pages (from-to)	3161-3177
Number of pages	17
Journal	Dalton Transactions
Volume	50
Issue number	9
DOIs	https://doi.org/10.1039/d0dt04051g
Publication status	Published - 7 Mar 2021

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title = "Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity",

abstract = "Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.",

author = "Mauro Ravera and Elisabetta Gabano and Ilaria Zanellato and Beatrice Rangone and Elena Perin and Beatrice Ferrari and Bottone, \{Maria Grazia\} and Domenico Osella",

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doi = "10.1039/d0dt04051g",

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T1 - Cis,cis,trans-[PtIVCl2(NH3)2(perillato)2], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

AU - Ravera, Mauro

AU - Gabano, Elisabetta

AU - Zanellato, Ilaria

AU - Rangone, Beatrice

AU - Perin, Elena

AU - Ferrari, Beatrice

AU - Bottone, Maria Grazia

AU - Osella, Domenico

PY - 2021/3/7

Y1 - 2021/3/7

N2 - Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.

AB - Two Pt(iv) conjugates containing one or two molecules of perillic acid (4-isopropenylcyclohexene-1-carboxylic acid), an active metabolite of limonene, were synthesized both with traditional and microwave-assisted methods and characterized. Their antiproliferative activity was tested on a panel of human tumor cell lines. In particular,cis,cis,trans-[PtIVCl2(NH3)2(perillato)2] exhibited excellent antiproliferative and antimetastatic activity on A-549 lung tumor cells at nanomolar concentrations. A number ofin vitrobiological tests were performed to decipher some aspects of its mechanism of action, including transwell migration and invasion as well as wound healing assay.

UR - https://www.scopus.com/pages/publications/85102282866

U2 - 10.1039/d0dt04051g

DO - 10.1039/d0dt04051g

M3 - Article

SN - 1477-9226

VL - 50

SP - 3161

EP - 3177

JO - Dalton Transactions

JF - Dalton Transactions

IS - 9

ER -

Cis,cis,trans-[Pt^IVCl₂(NH₃)₂(perillato)₂], a dual-action prodrug with excellent cytotoxic and antimetastatic activity

Abstract

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