Chronic GM1 ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat

Gino Toffano; Gian Enrico Savoini; Flavio Moroni; Grazia Lombardi; Laura Calzà; L. F. Agnati

doi:10.1016/0006-8993(84)90061-1

Chronic GM₁ ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat

Gino Toffano
, Gian Enrico Savoini
, Flavio Moroni
, Grazia Lombardi
, Laura Calzà
, L. F. Agnati

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of GM₁ gangliosise on the recovery of dopaminergic nigro-striatal neurons was studied in rats after unilateral hemitransection. GM₁ treatment partially prevented the decrease of tyrosine hydroxylase (TH) activity caused by hemitransection in the substantia nigra ipsilateral to the lesion. Concimitantly a significant increase of TH-immunoreactivity in the substantia nigra was also detected. In particular, chronic treatment with GM₁ prevented the disappearance of TH-positive cell bodies in the substantia nigra and induced the appearance of longer TH-positive dendrites with respect to the saline treatment. These data indicate that GM₁ treatment maintains the number of dopaminergic cell bodies in the substantia nigra after hemitransection by protecting against retrograde neuronal degeneration.

Original language	English
Pages (from-to)	233-239
Number of pages	7
Journal	Brain Research
Volume	296
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(84)90061-1
Publication status	Published - 2 Apr 1984
Externally published	Yes

Keywords

GM ganglioside
cell survival
hemitransection
immunohistochemistry
nigro-striatal DA neurons

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10.1016/0006-8993(84)90061-1

Cite this

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title = "Chronic GM1 ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat",

abstract = "The effect of GM1 gangliosise on the recovery of dopaminergic nigro-striatal neurons was studied in rats after unilateral hemitransection. GM1 treatment partially prevented the decrease of tyrosine hydroxylase (TH) activity caused by hemitransection in the substantia nigra ipsilateral to the lesion. Concimitantly a significant increase of TH-immunoreactivity in the substantia nigra was also detected. In particular, chronic treatment with GM1 prevented the disappearance of TH-positive cell bodies in the substantia nigra and induced the appearance of longer TH-positive dendrites with respect to the saline treatment. These data indicate that GM1 treatment maintains the number of dopaminergic cell bodies in the substantia nigra after hemitransection by protecting against retrograde neuronal degeneration.",

keywords = "GM ganglioside, cell survival, hemitransection, immunohistochemistry, nigro-striatal DA neurons",

author = "Gino Toffano and \{Enrico Savoini\}, Gian and Flavio Moroni and Grazia Lombardi and Laura Calz{\`a} and Agnati, \{L. F.\}",

year = "1984",

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doi = "10.1016/0006-8993(84)90061-1",

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T1 - Chronic GM1 ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat

AU - Toffano, Gino

AU - Enrico Savoini, Gian

AU - Moroni, Flavio

AU - Lombardi, Grazia

AU - Calzà, Laura

AU - Agnati, L. F.

PY - 1984/4/2

Y1 - 1984/4/2

N2 - The effect of GM1 gangliosise on the recovery of dopaminergic nigro-striatal neurons was studied in rats after unilateral hemitransection. GM1 treatment partially prevented the decrease of tyrosine hydroxylase (TH) activity caused by hemitransection in the substantia nigra ipsilateral to the lesion. Concimitantly a significant increase of TH-immunoreactivity in the substantia nigra was also detected. In particular, chronic treatment with GM1 prevented the disappearance of TH-positive cell bodies in the substantia nigra and induced the appearance of longer TH-positive dendrites with respect to the saline treatment. These data indicate that GM1 treatment maintains the number of dopaminergic cell bodies in the substantia nigra after hemitransection by protecting against retrograde neuronal degeneration.

AB - The effect of GM1 gangliosise on the recovery of dopaminergic nigro-striatal neurons was studied in rats after unilateral hemitransection. GM1 treatment partially prevented the decrease of tyrosine hydroxylase (TH) activity caused by hemitransection in the substantia nigra ipsilateral to the lesion. Concimitantly a significant increase of TH-immunoreactivity in the substantia nigra was also detected. In particular, chronic treatment with GM1 prevented the disappearance of TH-positive cell bodies in the substantia nigra and induced the appearance of longer TH-positive dendrites with respect to the saline treatment. These data indicate that GM1 treatment maintains the number of dopaminergic cell bodies in the substantia nigra after hemitransection by protecting against retrograde neuronal degeneration.

KW - GM ganglioside

KW - cell survival

KW - hemitransection

KW - immunohistochemistry

KW - nigro-striatal DA neurons

UR - https://www.scopus.com/pages/publications/0021289005

U2 - 10.1016/0006-8993(84)90061-1

DO - 10.1016/0006-8993(84)90061-1

M3 - Article

SN - 0006-8993

VL - 296

SP - 233

EP - 239

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Chronic GM₁ ganglioside treatment reduces dopamine cell body degeneration in the substantia nigra after unilateral hemitransection in rat

Abstract

Keywords

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