Characterization of anti-coagulant properties of prenylated coumarin ferulenol

Monia Monti; Mirko Pinotti; Giovanni Appendino; Franco Dallocchio; Tiziana Bellini; Fabiana Antognoni; Ferruccio Poli; Francesco Bernardi

doi:10.1016/j.bbagen.2007.06.013

Characterization of anti-coagulant properties of prenylated coumarin ferulenol

Monia Monti, Mirko Pinotti, Giovanni Appendino, Franco Dallocchio, Tiziana Bellini, Fabiana Antognoni, Ferruccio Poli, Francesco Bernardi

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.

Original language	English
Pages (from-to)	1437-1440
Number of pages	4
Journal	Biochimica et Biophysica Acta - General Subjects
Volume	1770
Issue number	10
DOIs	https://doi.org/10.1016/j.bbagen.2007.06.013
Publication status	Published - Oct 2007
Externally published	Yes

Keywords

Blood coagulation
Cellular models
Factor X
Ferulenol
Haemorrhagic tendency

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10.1016/j.bbagen.2007.06.013

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title = "Characterization of anti-coagulant properties of prenylated coumarin ferulenol",

abstract = "We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40\% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.",

keywords = "Blood coagulation, Cellular models, Factor X, Ferulenol, Haemorrhagic tendency",

author = "Monia Monti and Mirko Pinotti and Giovanni Appendino and Franco Dallocchio and Tiziana Bellini and Fabiana Antognoni and Ferruccio Poli and Francesco Bernardi",

note = "Funding Information: This work was supported by Grants from Ferrara University (MM, MP, FB, FD, TB), Bologna University (FP, FA) and Piemonte Orientale University (GA). The study was supported by MIUR-COFIN (MM, MP, FB), Telethon (GGP05214) (MP, FB) and Carife (FD, TB).",

year = "2007",

month = oct,

doi = "10.1016/j.bbagen.2007.06.013",

language = "English",

volume = "1770",

pages = "1437--1440",

journal = "Biochimica et Biophysica Acta - General Subjects",

issn = "0304-4165",

publisher = "Elsevier",

number = "10",

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TY - JOUR

T1 - Characterization of anti-coagulant properties of prenylated coumarin ferulenol

AU - Monti, Monia

AU - Pinotti, Mirko

AU - Appendino, Giovanni

AU - Dallocchio, Franco

AU - Bellini, Tiziana

AU - Antognoni, Fabiana

AU - Poli, Ferruccio

AU - Bernardi, Francesco

N1 - Funding Information: This work was supported by Grants from Ferrara University (MM, MP, FB, FD, TB), Bologna University (FP, FA) and Piemonte Orientale University (GA). The study was supported by MIUR-COFIN (MM, MP, FB), Telethon (GGP05214) (MP, FB) and Carife (FD, TB).

PY - 2007/10

Y1 - 2007/10

N2 - We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.

AB - We investigated the mechanisms underlying severe bleeding occurring upon consumption of Ferula communis. The prenylated coumarin ferulenol extracted from this plant did not directly affect blood coagulation but showed hepatocyte cytotoxicity and, at non-cytotoxic concentrations (< 100 nM), impaired factor X biosynthesis (40% reduction). Studies with ferulenol derivatives indicated the prenyl residue as major determinant of ferulenol activity.

KW - Blood coagulation

KW - Cellular models

KW - Factor X

KW - Ferulenol

KW - Haemorrhagic tendency

UR - https://www.scopus.com/pages/publications/34548582172

U2 - 10.1016/j.bbagen.2007.06.013

DO - 10.1016/j.bbagen.2007.06.013

M3 - Article

SN - 0304-4165

VL - 1770

SP - 1437

EP - 1440

JO - Biochimica et Biophysica Acta - General Subjects

JF - Biochimica et Biophysica Acta - General Subjects

IS - 10

ER -

Characterization of anti-coagulant properties of prenylated coumarin ferulenol

Abstract

Keywords

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