Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury

Giuseppe Poli; Elena Chiarpotto; Emanuele Albano; Damiano Cottalasso; Giorgio Nanni; Umberto M. Marinari; Anna M. Bassi; Mario U. Dianzani

doi:10.1016/0024-3205(85)90634-4

Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury

Giuseppe Poli
, Elena Chiarpotto
, Emanuele Albano
, Damiano Cottalasso
, Giorgio Nanni
, Umberto M. Marinari
, Anna M. Bassi
, Mario U. Dianzani

Research output: Contribution to journal › Article › peer-review

Abstract

Functional change of liver Golgi apparatus during carbon tetrachloride (CCl₄) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.

Original language	English
Pages (from-to)	533-539
Number of pages	7
Journal	Life Sciences
Volume	36
Issue number	6
DOIs	https://doi.org/10.1016/0024-3205(85)90634-4
Publication status	Published - 11 Feb 1985
Externally published	Yes

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title = "Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury",

abstract = "Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The {"}in vitro{"} experimental model provided evidence of Golgi derangement early after giving the haloalkane. The {"}in vivo{"} analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.",

author = "Giuseppe Poli and Elena Chiarpotto and Emanuele Albano and Damiano Cottalasso and Giorgio Nanni and Marinari, \{Umberto M.\} and Bassi, \{Anna M.\} and Dianzani, \{Mario U.\}",

note = "Funding Information: The Authors wish to thank the National Foundation for Cancer Research, Bethesda, Maryland, U.S.A., and the Consiglio Nazionale delle Ricerche, Roma, Italy, for financial support. The critical discussion of the reported work with Prof. T.F. Slater and Dr. K.H. Cheeseman has also been appreciated.",

year = "1985",

month = feb,

day = "11",

doi = "10.1016/0024-3205(85)90634-4",

language = "English",

volume = "36",

pages = "533--539",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

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}

TY - JOUR

T1 - Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion

T2 - Functional impairment of Golgi apparatus in the early phases of such injury

AU - Poli, Giuseppe

AU - Chiarpotto, Elena

AU - Albano, Emanuele

AU - Cottalasso, Damiano

AU - Nanni, Giorgio

AU - Marinari, Umberto M.

AU - Bassi, Anna M.

AU - Dianzani, Mario U.

N1 - Funding Information: The Authors wish to thank the National Foundation for Cancer Research, Bethesda, Maryland, U.S.A., and the Consiglio Nazionale delle Ricerche, Roma, Italy, for financial support. The critical discussion of the reported work with Prof. T.F. Slater and Dr. K.H. Cheeseman has also been appreciated.

PY - 1985/2/11

Y1 - 1985/2/11

N2 - Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.

AB - Functional change of liver Golgi apparatus during carbon tetrachloride (CCl4) poisoning was demonstrated both in rat isolated hepatocytes and in the whole animal. The "in vitro" experimental model provided evidence of Golgi derangement early after giving the haloalkane. The "in vivo" analyses also showed that such an alteration involves both formative and secretory sides of the subcellular structure.

UR - https://www.scopus.com/pages/publications/0021969635

U2 - 10.1016/0024-3205(85)90634-4

DO - 10.1016/0024-3205(85)90634-4

M3 - Article

SN - 0024-3205

VL - 36

SP - 533

EP - 539

JO - Life Sciences

JF - Life Sciences

IS - 6

ER -

Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: Functional impairment of Golgi apparatus in the early phases of such injury

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