Cancer related inflammation: The macrophage connection

Antonio Sica; Paola Allavena; Alberto Mantovani

doi:10.1016/j.canlet.2008.03.028

Cancer related inflammation: The macrophage connection

Antonio Sica
, Paola Allavena
, Alberto Mantovani

Research output: Contribution to journal › Review article › peer-review

Abstract

Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

Original language	English
Pages (from-to)	204-215
Number of pages	12
Journal	Cancer Letters
Volume	267
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2008.03.028
Publication status	Published - 28 Aug 2008
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Angiogenesis
Cancer
Chemokines
Cytokines
Inflammation
Macrophage polarization
Therapeutic targets
Tumor promotion
Tumor-associated macrophages

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10.1016/j.canlet.2008.03.028

Cite this

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title = "Cancer related inflammation: The macrophage connection",

abstract = "Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.",

keywords = "Angiogenesis, Cancer, Chemokines, Cytokines, Inflammation, Macrophage polarization, Therapeutic targets, Tumor promotion, Tumor-associated macrophages",

author = "Antonio Sica and Paola Allavena and Alberto Mantovani",

note = "Funding Information: This work was supported by Associazione Italiana Ricerca sul Cancro (AIRC), Italy; European Community and Ministero Istruzione Universit{\`a} Ricerca (MIUR), Italy; Istituto Superiore Sanita{\textquoteright} (ISS).",

year = "2008",

month = aug,

day = "28",

doi = "10.1016/j.canlet.2008.03.028",

language = "English",

volume = "267",

pages = "204--215",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Cancer related inflammation

T2 - The macrophage connection

AU - Sica, Antonio

AU - Allavena, Paola

AU - Mantovani, Alberto

N1 - Funding Information: This work was supported by Associazione Italiana Ricerca sul Cancro (AIRC), Italy; European Community and Ministero Istruzione Università Ricerca (MIUR), Italy; Istituto Superiore Sanita’ (ISS).

PY - 2008/8/28

Y1 - 2008/8/28

N2 - Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

AB - Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases, promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches.

KW - Angiogenesis

KW - Cancer

KW - Chemokines

KW - Cytokines

KW - Inflammation

KW - Macrophage polarization

KW - Therapeutic targets

KW - Tumor promotion

KW - Tumor-associated macrophages

UR - https://www.scopus.com/pages/publications/47749155653

U2 - 10.1016/j.canlet.2008.03.028

DO - 10.1016/j.canlet.2008.03.028

M3 - Review article

SN - 0304-3835

VL - 267

SP - 204

EP - 215

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Cancer related inflammation: The macrophage connection

Abstract

UN SDGs

Keywords

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