Biological properties of benzodifuran derivatives

I. Viano; C. Dianzani; O. Gia; S. Gastaldi; E. Genazzani

Biological properties of benzodifuran derivatives

I. Viano
, C. Dianzani
, O. Gia
, S. Gastaldi
, E. Genazzani

Research output: Contribution to journal › Article › peer-review

Abstract

The antiviral activity and the effect on DNA synthesis of two benzodifuran compounds were studied. DNA and some RNA viruses were significantly inhibited by concentrations ranging from 15 to 30 nM/ml. The inhibition of DNA synthesis in host cells was obtained with concentrations higher than those inhibiting virus replication. A favourable ratio between antiviral activity and inhibiton of DNA synthesis of the host cells is present in these compounds. This activity is substantially due to the ability of the compounds to complex with DNA.

Original language	English
Pages (from-to)	865-867
Number of pages	3
Journal	Drugs under Experimental and Clinical Research
Volume	11
Issue number	12
Publication status	Published - 1985
Externally published	Yes

Cite this

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title = "Biological properties of benzodifuran derivatives",

abstract = "The antiviral activity and the effect on DNA synthesis of two benzodifuran compounds were studied. DNA and some RNA viruses were significantly inhibited by concentrations ranging from 15 to 30 nM/ml. The inhibition of DNA synthesis in host cells was obtained with concentrations higher than those inhibiting virus replication. A favourable ratio between antiviral activity and inhibiton of DNA synthesis of the host cells is present in these compounds. This activity is substantially due to the ability of the compounds to complex with DNA.",

author = "I. Viano and C. Dianzani and O. Gia and S. Gastaldi and E. Genazzani",

year = "1985",

language = "English",

volume = "11",

pages = "865--867",

journal = "Drugs under Experimental and Clinical Research",

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TY - JOUR

T1 - Biological properties of benzodifuran derivatives

AU - Viano, I.

AU - Dianzani, C.

AU - Gia, O.

AU - Gastaldi, S.

AU - Genazzani, E.

PY - 1985

Y1 - 1985

N2 - The antiviral activity and the effect on DNA synthesis of two benzodifuran compounds were studied. DNA and some RNA viruses were significantly inhibited by concentrations ranging from 15 to 30 nM/ml. The inhibition of DNA synthesis in host cells was obtained with concentrations higher than those inhibiting virus replication. A favourable ratio between antiviral activity and inhibiton of DNA synthesis of the host cells is present in these compounds. This activity is substantially due to the ability of the compounds to complex with DNA.

AB - The antiviral activity and the effect on DNA synthesis of two benzodifuran compounds were studied. DNA and some RNA viruses were significantly inhibited by concentrations ranging from 15 to 30 nM/ml. The inhibition of DNA synthesis in host cells was obtained with concentrations higher than those inhibiting virus replication. A favourable ratio between antiviral activity and inhibiton of DNA synthesis of the host cells is present in these compounds. This activity is substantially due to the ability of the compounds to complex with DNA.

UR - https://www.scopus.com/pages/publications/0022347029

M3 - Article

SN - 0378-6501

VL - 11

SP - 865

EP - 867

JO - Drugs under Experimental and Clinical Research

JF - Drugs under Experimental and Clinical Research

IS - 12

ER -

Biological properties of benzodifuran derivatives

Abstract

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