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Biodegradable micro and nanoparticles for controlled drug release

  • C. Mattu
  • , S. Sartori
  • , E. Ranzato
  • , M. Boffito
  • , R. Li
  • , G. Ciardelli

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this paper, we propose the encapsulation of the anticancer drug Paclitaxel into biodegrdable polymeric carriers to improve the release properties of the active principle. Commercial polyesthers, such as Poly-ε-Caprolactone (PCL) or Poly Lactic Acid (PLA) and a series of proprietary polyester-urethanes (PU) were selected to prepare micro or nanoparticles for controlled drug release. The Solvent Displacement Method or the Oil in Water single Emulsion Solvent Extraction Evaporation Method were optimized to prepare colloidal carriers with tunable release profiles and encapsulation properties.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Pages314-317
Number of pages4
Publication statusPublished - 2011
EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
Duration: 13 Jun 201116 Jun 2011

Publication series

NameTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Volume3

Conference

ConferenceNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
Country/TerritoryUnited States
CityBoston, MA
Period13/06/1116/06/11

Keywords

  • Microparticles
  • Nanoparticles
  • Paclitaxel
  • Polyesters
  • Polyurethanes

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