Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): Clinical feasibility and dosimetric results of a single patient

Pierfrancesco Franco; Fernanda Migliaccio; Paolo Torielli; Piera Sciacero; Giuseppe Girelli; Domenico Cante; Cecilia Arrichiello; Valeria Casanova Borca; Andrea Peruzzo Cornetto; Gianmauro Numico; Maria Rosa La Porta; Santi Tofani; Umberto Ricardi

doi:10.5301/tj.5000264

Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): Clinical feasibility and dosimetric results of a single patient

Pierfrancesco Franco, Fernanda Migliaccio, Paolo Torielli, Piera Sciacero, Giuseppe Girelli, Domenico Cante, Cecilia Arrichiello, Valeria Casanova Borca, Andrea Peruzzo Cornetto, Gianmauro Numico, Maria Rosa La Porta, Santi Tofani, Umberto Ricardi

Research output: Contribution to journal › Article › peer-review

Abstract

We herein report on a case of synchronous bilateral breast cancer patient undergoing adjuvant intensity-modulated whole breast with static angle tomotherapy (TomoDirect). The patient was treated with a hypofractionated schedule employing a simultaneous integrated boost approach. Radiotherapy schedule was 45 Gy/20 fractions (2.25 Gy daily) to the bilateral whole breast and 50 Gy/20 fractions (2.5 Gy daily) to the 2 lumpectomy cavities. Treatment was delivered over 4 weeks. Dosimetric results were robust with consistent target coverage and adequate normal tissue avoidance. Treatment was generally well-tolerated and acute toxicity profile was mild. The present report highlights the promising clinical feasibility of TomoDirect for bilateral breast irradiation.

Original language	English
Pages (from-to)	e4-e8
Journal	Tumori
Volume	101
Issue number	1
DOIs	https://doi.org/10.5301/tj.5000264
Publication status	Published - 1 Jan 2015
Externally published	Yes

Keywords

Adjuvant whole breast radiotherapy
Bilateral breast cancer
Hypofractionation
Simultaneous integrated boost
Tomotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5301/tj.5000264

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Franco, P., Migliaccio, F., Torielli, P., Sciacero, P., Girelli, G., Cante, D., Arrichiello, C., Borca, V. C., Cornetto, A. P., Numico, G., La Porta, M. R., Tofani, S., & Ricardi, U. (2015). Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): Clinical feasibility and dosimetric results of a single patient. Tumori, 101(1), e4-e8. https://doi.org/10.5301/tj.5000264

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title = "Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): Clinical feasibility and dosimetric results of a single patient",

abstract = "We herein report on a case of synchronous bilateral breast cancer patient undergoing adjuvant intensity-modulated whole breast with static angle tomotherapy (TomoDirect). The patient was treated with a hypofractionated schedule employing a simultaneous integrated boost approach. Radiotherapy schedule was 45 Gy/20 fractions (2.25 Gy daily) to the bilateral whole breast and 50 Gy/20 fractions (2.5 Gy daily) to the 2 lumpectomy cavities. Treatment was delivered over 4 weeks. Dosimetric results were robust with consistent target coverage and adequate normal tissue avoidance. Treatment was generally well-tolerated and acute toxicity profile was mild. The present report highlights the promising clinical feasibility of TomoDirect for bilateral breast irradiation.",

keywords = "Adjuvant whole breast radiotherapy, Bilateral breast cancer, Hypofractionation, Simultaneous integrated boost, Tomotherapy",

author = "Pierfrancesco Franco and Fernanda Migliaccio and Paolo Torielli and Piera Sciacero and Giuseppe Girelli and Domenico Cante and Cecilia Arrichiello and Borca, {Valeria Casanova} and Cornetto, {Andrea Peruzzo} and Gianmauro Numico and {La Porta}, {Maria Rosa} and Santi Tofani and Umberto Ricardi",

note = "Publisher Copyright: {\textcopyright} 2015 INTM, Italy. Published by Wichtig Publishing.",

year = "2015",

month = jan,

day = "1",

doi = "10.5301/tj.5000264",

language = "English",

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Franco, P, Migliaccio, F, Torielli, P, Sciacero, P, Girelli, G, Cante, D, Arrichiello, C, Borca, VC, Cornetto, AP, Numico, G, La Porta, MR, Tofani, S & Ricardi, U 2015, 'Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): Clinical feasibility and dosimetric results of a single patient', Tumori, vol. 101, no. 1, pp. e4-e8. https://doi.org/10.5301/tj.5000264

TY - JOUR

T1 - Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect)

T2 - Clinical feasibility and dosimetric results of a single patient

AU - Franco, Pierfrancesco

AU - Migliaccio, Fernanda

AU - Torielli, Paolo

AU - Sciacero, Piera

AU - Girelli, Giuseppe

AU - Cante, Domenico

AU - Arrichiello, Cecilia

AU - Borca, Valeria Casanova

AU - Cornetto, Andrea Peruzzo

AU - Numico, Gianmauro

AU - La Porta, Maria Rosa

AU - Tofani, Santi

AU - Ricardi, Umberto

PY - 2015/1/1

Y1 - 2015/1/1

N2 - We herein report on a case of synchronous bilateral breast cancer patient undergoing adjuvant intensity-modulated whole breast with static angle tomotherapy (TomoDirect). The patient was treated with a hypofractionated schedule employing a simultaneous integrated boost approach. Radiotherapy schedule was 45 Gy/20 fractions (2.25 Gy daily) to the bilateral whole breast and 50 Gy/20 fractions (2.5 Gy daily) to the 2 lumpectomy cavities. Treatment was delivered over 4 weeks. Dosimetric results were robust with consistent target coverage and adequate normal tissue avoidance. Treatment was generally well-tolerated and acute toxicity profile was mild. The present report highlights the promising clinical feasibility of TomoDirect for bilateral breast irradiation.

AB - We herein report on a case of synchronous bilateral breast cancer patient undergoing adjuvant intensity-modulated whole breast with static angle tomotherapy (TomoDirect). The patient was treated with a hypofractionated schedule employing a simultaneous integrated boost approach. Radiotherapy schedule was 45 Gy/20 fractions (2.25 Gy daily) to the bilateral whole breast and 50 Gy/20 fractions (2.5 Gy daily) to the 2 lumpectomy cavities. Treatment was delivered over 4 weeks. Dosimetric results were robust with consistent target coverage and adequate normal tissue avoidance. Treatment was generally well-tolerated and acute toxicity profile was mild. The present report highlights the promising clinical feasibility of TomoDirect for bilateral breast irradiation.

KW - Adjuvant whole breast radiotherapy

KW - Bilateral breast cancer

KW - Hypofractionation

KW - Simultaneous integrated boost

KW - Tomotherapy

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U2 - 10.5301/tj.5000264

DO - 10.5301/tj.5000264

M3 - Article

SN - 0300-8916

VL - 101

SP - e4-e8

JO - Tumori

JF - Tumori

IS - 1

ER -

Bilateral breast radiation delivered with static angle tomotherapy (TomoDirect): Clinical feasibility and dosimetric results of a single patient

Abstract

Keywords

UN SDGs

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