Bifunctional ligands based on the DOTA-monoamide cage

Alessandro Barge; Lorenzo Tei; Dharita Upadhyaya; Franco Fedeli; Lorena Beltrami; Rachele Stefanìa; Silvio Aime; Giancarlo Cravotto

doi:10.1039/b715844k

Bifunctional ligands based on the DOTA-monoamide cage

Alessandro Barge, Lorenzo Tei, Dharita Upadhyaya, Franco Fedeli, Lorena Beltrami, Rachele Stefanìa, Silvio Aime, Giancarlo Cravotto

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

Original language	English
Pages (from-to)	1176-1184
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	6
Issue number	7
DOIs	https://doi.org/10.1039/b715844k
Publication status	Published - 2008

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abstract = "Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.",

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AU - Barge, Alessandro

AU - Tei, Lorenzo

AU - Upadhyaya, Dharita

AU - Fedeli, Franco

AU - Beltrami, Lorena

AU - Stefanìa, Rachele

AU - Aime, Silvio

AU - Cravotto, Giancarlo

PY - 2008

Y1 - 2008

N2 - Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

AB - Efficient routes to DOTA-monoamide ligands bearing amino, hydroxyl, aldehyde and maleimido groups are described. These functional groups, which can be spaced at will from the coordination cage, will readily react with suitable groups of targeting moieties. Bioconjugates obtained in this way can be used for diagnostic imaging and therapeutic applications.

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U2 - 10.1039/b715844k

DO - 10.1039/b715844k

M3 - Article

SN - 1477-0520

VL - 6

SP - 1176

EP - 1184

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 7

ER -

Bifunctional ligands based on the DOTA-monoamide cage

Abstract

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