Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction

Elena Mele; Maria Antonietta Riemma; Maria Donniacuo; Marialucia Telesca; Grazia Sorrentino; DOMENICO D'AMARIO; Filippo Scialò; Eleonora Cianflone; Donato Cappetta; Daniele Torella; Giuseppe Castaldo; Francesco Rossi; Liberato Berrino; Konrad Urbanek; Antonella De Angelis

doi:10.1186/s12933-026-03133-z

Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction

Elena Mele
, Maria Antonietta Riemma
, Maria Donniacuo
, Marialucia Telesca
, Grazia Sorrentino
, DOMENICO D'AMARIO
, Filippo Scialò
, Eleonora Cianflone
, Donato Cappetta
, Daniele Torella
, Giuseppe Castaldo
, Francesco Rossi
, Liberato Berrino
, Konrad Urbanek
, Antonella De Angelis

Department of Translational Medicine

Research output: Contribution to journal › Article

Original language	English
Journal	Cardiovascular Diabetology
DOIs	https://doi.org/10.1186/s12933-026-03133-z
Publication status	Published - 2026

Keywords

ARNi
Ageing
Cardiometabolic HFpEF
Female sex
SGLT2i

Access to Document

10.1186/s12933-026-03133-z

https://hdl.handle.net/11579/229223

Cite this

Mele, E., Riemma, M. A., Donniacuo, M., Telesca, M., Sorrentino, G., D'AMARIO, DOMENICO., Scialò, F., Cianflone, E., Cappetta, D., Torella, D., Castaldo, G., Rossi, F., Berrino, L., Urbanek, K., & De Angelis, A. (2026). Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction. Cardiovascular Diabetology. https://doi.org/10.1186/s12933-026-03133-z

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title = "Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction",

keywords = "ARNi, Ageing, Cardiometabolic HFpEF, Female sex, SGLT2i, ARNi, Ageing, Cardiometabolic HFpEF, Female sex, SGLT2i",

author = "Elena Mele and Riemma, \{Maria Antonietta\} and Maria Donniacuo and Marialucia Telesca and Grazia Sorrentino and DOMENICO D'AMARIO and Filippo Scial{\`o} and Eleonora Cianflone and Donato Cappetta and Daniele Torella and Giuseppe Castaldo and Francesco Rossi and Liberato Berrino and Konrad Urbanek and \{De Angelis\}, Antonella",

year = "2026",

doi = "10.1186/s12933-026-03133-z",

language = "English",

journal = "Cardiovascular Diabetology",

issn = "1475-2840",

publisher = "BioMed Central Ltd.",

}

Mele, E, Riemma, MA, Donniacuo, M, Telesca, M, Sorrentino, G, D'AMARIO, DOMENICO, Scialò, F, Cianflone, E, Cappetta, D, Torella, D, Castaldo, G, Rossi, F, Berrino, L, Urbanek, K & De Angelis, A 2026, 'Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction', Cardiovascular Diabetology. https://doi.org/10.1186/s12933-026-03133-z

TY - JOUR

T1 - Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction

AU - Mele, Elena

AU - Riemma, Maria Antonietta

AU - Donniacuo, Maria

AU - Telesca, Marialucia

AU - Sorrentino, Grazia

AU - D'AMARIO, DOMENICO

AU - Scialò, Filippo

AU - Cianflone, Eleonora

AU - Cappetta, Donato

AU - Torella, Daniele

AU - Castaldo, Giuseppe

AU - Rossi, Francesco

AU - Berrino, Liberato

AU - Urbanek, Konrad

AU - De Angelis, Antonella

PY - 2026

Y1 - 2026

KW - ARNi

KW - Ageing

KW - Cardiometabolic HFpEF

KW - Female sex

KW - SGLT2i

KW - ARNi

KW - Ageing

KW - Cardiometabolic HFpEF

KW - Female sex

KW - SGLT2i

UR - https://iris.uniupo.it/handle/11579/229223

U2 - 10.1186/s12933-026-03133-z

DO - 10.1186/s12933-026-03133-z

M3 - Article

SN - 1475-2840

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

ER -

Benefits of sacubitril/valsartan alone and in combination with dapagliflozin in a preclinical female model of cardiometabolic and age-related cardiac dysfunction

Keywords

Access to Document

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Cite this