Abstract
Chronic administration of a choline-deficient diet for 20 days caused no modification in ACh levels in the cortex, hippocampus and olfactory system of the rat and an increase in the density (B(max)) of the muscarinic receptors in the hippocampus. The choline-deficient diet caused no modification in noradrenaline levels and a reduction in the density of α1-adrenoceptors in the cortex, hippocampus and olfactory system. This paper discusses the possibility that these neurochemical effects are correlated with the reduction in spontaneous memory decay which was observed in the staircase maze after 20 days of a choline-deficient diet.
Original language | English |
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Pages (from-to) | 145-150 |
Number of pages | 6 |
Journal | Behavioural Brain Research |
Volume | 84 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - Mar 1997 |
Externally published | Yes |
Keywords
- acetylcholine
- choline-deficient diet
- memory decay
- muscarinic receptor
- noradrenaline
- α-adrenoreceptor