Behavioral and neurochemical effects of a chronic choline-deficient diet in the rat

Luigi Molinengo, Marco Orsetti, Piera Ghi

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic administration of a choline-deficient diet for 20 days caused no modification in ACh levels in the cortex, hippocampus and olfactory system of the rat and an increase in the density (B(max)) of the muscarinic receptors in the hippocampus. The choline-deficient diet caused no modification in noradrenaline levels and a reduction in the density of α1-adrenoceptors in the cortex, hippocampus and olfactory system. This paper discusses the possibility that these neurochemical effects are correlated with the reduction in spontaneous memory decay which was observed in the staircase maze after 20 days of a choline-deficient diet.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalBehavioural Brain Research
Volume84
Issue number1-2
DOIs
Publication statusPublished - Mar 1997
Externally publishedYes

Keywords

  • acetylcholine
  • choline-deficient diet
  • memory decay
  • muscarinic receptor
  • noradrenaline
  • α-adrenoreceptor

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