ATP-citrate lyase is essential for macrophage inflammatory response

Vittoria Infantino; Vito Iacobazzi; Ferdinando Palmieri; Alessio Menga

doi:10.1016/j.bbrc.2013.09.037

ATP-citrate lyase is essential for macrophage inflammatory response

Vittoria Infantino
, Vito Iacobazzi
, Ferdinando Palmieri
, Alessio Menga

Research output: Contribution to journal › Article › peer-review

Abstract

Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism.

Original language	English
Pages (from-to)	105-111
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	440
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2013.09.037
Publication status	Published - 11 Oct 2013
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ATP-citrate lyase
Immunometabolism
Inflammation
Nitric oxide
Prostaglandin E2
Reactive oxygen species

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10.1016/j.bbrc.2013.09.037

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title = "ATP-citrate lyase is essential for macrophage inflammatory response",

abstract = "Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism.",

keywords = "ATP-citrate lyase, Immunometabolism, Inflammation, Nitric oxide, Prostaglandin E2, Reactive oxygen species",

author = "Vittoria Infantino and Vito Iacobazzi and Ferdinando Palmieri and Alessio Menga",

year = "2013",

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doi = "10.1016/j.bbrc.2013.09.037",

language = "English",

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TY - JOUR

T1 - ATP-citrate lyase is essential for macrophage inflammatory response

AU - Infantino, Vittoria

AU - Iacobazzi, Vito

AU - Palmieri, Ferdinando

AU - Menga, Alessio

PY - 2013/10/11

Y1 - 2013/10/11

N2 - Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism.

AB - Growing evidence suggests that energy metabolism and inflammation are closely linked and that cross-talk between these processes is fundamental to the pathogenesis of many human diseases. However, the molecular mechanisms underlying these observations are still poorly understood. Here we describe the key role of ATP-citrate lyase (ACLY) in inflammation. We find that ACLY mRNA and protein levels markedly and quickly increase in activated macrophages. Importantly, ACLY activity inhibition as well as ACLY gene silencing lead to reduced nitric oxide, reactive oxygen species and prostaglandin E2 inflammatory mediators. In conclusion, we present a direct role for ACLY in macrophage inflammatory metabolism.

KW - ATP-citrate lyase

KW - Immunometabolism

KW - Inflammation

KW - Nitric oxide

KW - Prostaglandin E2

KW - Reactive oxygen species

UR - https://www.scopus.com/pages/publications/84885388000

U2 - 10.1016/j.bbrc.2013.09.037

DO - 10.1016/j.bbrc.2013.09.037

M3 - Article

SN - 0006-291X

VL - 440

SP - 105

EP - 111

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

ATP-citrate lyase is essential for macrophage inflammatory response

Abstract

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Keywords

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