Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

Jessica Cusato; Lucio Boglione; Amedeo De Nicolò; Rosaria Imbornone; Chiara Simona Cardellino; Valeria Ghisetti; Chiara Carcieri; Giuseppe Cariti; Giovanni Di Perri; Antonio D'Avolio

doi:10.2217/pgs-2016-0041

Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

Jessica Cusato, Lucio Boglione, Amedeo De Nicolò, Rosaria Imbornone, Chiara Simona Cardellino, Valeria Ghisetti, Chiara Carcieri, Giuseppe Cariti, Giovanni Di Perri, Antonio D'Avolio

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

Original language	English
Pages (from-to)	651-661
Number of pages	11
Journal	Pharmacogenomics
Volume	18
Issue number	7
DOIs	https://doi.org/10.2217/pgs-2016-0041
Publication status	Published - May 2017
Externally published	Yes

Keywords

VDR genes
calcitriol
pharmacogenetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/pgs-2016-0041

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title = "Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients",

abstract = "Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.",

keywords = "VDR genes, calcitriol, pharmacogenetics",

author = "Jessica Cusato and Lucio Boglione and {De Nicol{\`o}}, Amedeo and Rosaria Imbornone and Cardellino, {Chiara Simona} and Valeria Ghisetti and Chiara Carcieri and Giuseppe Cariti and {Di Perri}, Giovanni and Antonio D'Avolio",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = may,

doi = "10.2217/pgs-2016-0041",

language = "English",

volume = "18",

pages = "651--661",

journal = "Pharmacogenomics",

issn = "1462-2416",

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TY - JOUR

T1 - Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

AU - Cusato, Jessica

AU - Boglione, Lucio

AU - De Nicolò, Amedeo

AU - Imbornone, Rosaria

AU - Cardellino, Chiara Simona

AU - Ghisetti, Valeria

AU - Carcieri, Chiara

AU - Cariti, Giuseppe

AU - Di Perri, Giovanni

AU - D'Avolio, Antonio

PY - 2017/5

Y1 - 2017/5

N2 - Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

AB - Aim: Vitamin D modulates biological processes; an influence of vitamin D levels and genetic variants was identified concerning hepatitis B virus infection. We evaluated the role of some SNPs of vitamin D pathway genes in some clinical features of hepatitis B affected patients treated with pegylated interferon. Methods: We investigated SNPs in IL-28B, CYP27B1, CYP27A1, CYP24A1, VDBP and VDR genes, through real-time PCR. Results: VDRApaI SNP was associated to viral load and HBsAg presence at different timings. In logistic regression analyses, VDRApaI AA genotype predicted baseline viral load >6 Log IU/ml (marker of nonresponse), and both virological and biochemical responses. Conclusion: Pharmacogenetic data could help physicians in the prediction of patients with higher probability to achieve a good response.

KW - VDR genes

KW - calcitriol

KW - pharmacogenetics

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U2 - 10.2217/pgs-2016-0041

DO - 10.2217/pgs-2016-0041

M3 - Article

SN - 1462-2416

VL - 18

SP - 651

EP - 661

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 7

ER -

Association of Vitamin D pathway SNPs and clinical response to interferon in a cohort of HBeAg-negative patients

Abstract

Keywords

UN SDGs

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