Argyrophilic Nuclear Organizer Region Counts and Ki-67 Scores in Human Renal Cell Carcinoma

A. Pich; G. Valente; L. Azzoni; A. Stramignoni; E. Margaria; M. Tasso

doi:10.1016/S0344-0338(11)80011-7

Argyrophilic Nuclear Organizer Region Counts and Ki-67 Scores in Human Renal Cell Carcinoma

A. Pich, G. Valente, L. Azzoni, A. Stramignoni, E. Margaria, M. Tasso

Research output: Contribution to journal › Article › peer-review

Abstract

The proliferative activity of 21 cases of renal cell carcinoma has been investigated by means of monoclonal antibody Ki-67 and Nucleolar Organizer Regions (AgNORs) analysis. The correlation between AgNOR counts and Ki-67 scores was only slightly significant (r = 0.53, r² = 0.28) as determined by linear regression. Positive correlation was found between Ki-67 scores and tumour histologic grade. However, no correlation was observed between Ki-67 scores and tumour pathologic stage and between AgNOR counts and tumour histologic grade andl or pathologic stage. The results suggest that AgNOR counts cannot replace Ki-67 scores in evaluating the proli ferative activity of renal cell carcinoma and that such activity and both histologic grade and pathologic stage seem to be independent parametres.

Original language	English
Pages (from-to)	482-486
Number of pages	5
Journal	Pathology Research and Practice
Volume	187
Issue number	4
DOIs	https://doi.org/10.1016/S0344-0338(11)80011-7
Publication status	Published - 1991
Externally published	Yes

Keywords

Ki-67 monoclonal antibody
Nucleolar organizer regions
Renal cell carcinoma

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10.1016/S0344-0338(11)80011-7

Cite this

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title = "Argyrophilic Nuclear Organizer Region Counts and Ki-67 Scores in Human Renal Cell Carcinoma",

abstract = "The proliferative activity of 21 cases of renal cell carcinoma has been investigated by means of monoclonal antibody Ki-67 and Nucleolar Organizer Regions (AgNORs) analysis. The correlation between AgNOR counts and Ki-67 scores was only slightly significant (r = 0.53, r2 = 0.28) as determined by linear regression. Positive correlation was found between Ki-67 scores and tumour histologic grade. However, no correlation was observed between Ki-67 scores and tumour pathologic stage and between AgNOR counts and tumour histologic grade andl or pathologic stage. The results suggest that AgNOR counts cannot replace Ki-67 scores in evaluating the proli ferative activity of renal cell carcinoma and that such activity and both histologic grade and pathologic stage seem to be independent parametres.",

keywords = "Ki-67 monoclonal antibody, Nucleolar organizer regions, Renal cell carcinoma",

author = "A. Pich and G. Valente and L. Azzoni and A. Stramignoni and E. Margaria and M. Tasso",

note = "Funding Information: 1 This work was supported by grants from the Italian MPT",

year = "1991",

doi = "10.1016/S0344-0338(11)80011-7",

language = "English",

volume = "187",

pages = "482--486",

journal = "Pathology Research and Practice",

issn = "0344-0338",

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TY - JOUR

T1 - Argyrophilic Nuclear Organizer Region Counts and Ki-67 Scores in Human Renal Cell Carcinoma

AU - Pich, A.

AU - Valente, G.

AU - Azzoni, L.

AU - Stramignoni, A.

AU - Margaria, E.

AU - Tasso, M.

N1 - Funding Information: 1 This work was supported by grants from the Italian MPT

PY - 1991

Y1 - 1991

N2 - The proliferative activity of 21 cases of renal cell carcinoma has been investigated by means of monoclonal antibody Ki-67 and Nucleolar Organizer Regions (AgNORs) analysis. The correlation between AgNOR counts and Ki-67 scores was only slightly significant (r = 0.53, r2 = 0.28) as determined by linear regression. Positive correlation was found between Ki-67 scores and tumour histologic grade. However, no correlation was observed between Ki-67 scores and tumour pathologic stage and between AgNOR counts and tumour histologic grade andl or pathologic stage. The results suggest that AgNOR counts cannot replace Ki-67 scores in evaluating the proli ferative activity of renal cell carcinoma and that such activity and both histologic grade and pathologic stage seem to be independent parametres.

AB - The proliferative activity of 21 cases of renal cell carcinoma has been investigated by means of monoclonal antibody Ki-67 and Nucleolar Organizer Regions (AgNORs) analysis. The correlation between AgNOR counts and Ki-67 scores was only slightly significant (r = 0.53, r2 = 0.28) as determined by linear regression. Positive correlation was found between Ki-67 scores and tumour histologic grade. However, no correlation was observed between Ki-67 scores and tumour pathologic stage and between AgNOR counts and tumour histologic grade andl or pathologic stage. The results suggest that AgNOR counts cannot replace Ki-67 scores in evaluating the proli ferative activity of renal cell carcinoma and that such activity and both histologic grade and pathologic stage seem to be independent parametres.

KW - Ki-67 monoclonal antibody

KW - Nucleolar organizer regions

KW - Renal cell carcinoma

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U2 - 10.1016/S0344-0338(11)80011-7

DO - 10.1016/S0344-0338(11)80011-7

M3 - Article

SN - 0344-0338

VL - 187

SP - 482

EP - 486

JO - Pathology Research and Practice

JF - Pathology Research and Practice

IS - 4

ER -

Argyrophilic Nuclear Organizer Region Counts and Ki-67 Scores in Human Renal Cell Carcinoma

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Keywords

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