Appraisal of the redox behaviour of the antimetastatic ruthenium(iii) complex [ImH][RuCl4(DMSO)(Im)], NAMI-A

Mauro Ravera, Sara Baracco, Claudio Cassino, Piero Zanello, Domenico Osella

Research output: Contribution to journalArticlepeer-review

Abstract

The imidazolium trans-tetrachloro(dimethylsulfoxide)imidazoleruthenate(iii) complex [ImH][Ru(iii)Cl4(DMSO)(Im)], NAMI-A, has shown an interesting antimetastatic activity. Since Ru(iii) complexes are coordinatively more inert than the corresponding Ru(ii) derivatives, an “activation by reduction” mechanism has been proposed to explain the biological activity of NAMI-A, thus acting as a pro-drug. We report here an electrochemical study on NAMI-A in aqueous solutions which emphasizes the structural and chemical consequences accompanying the easy Ru(iii)/Ru(ii) electron transfer (e.g., axial imidazole/water exchange in acidic solution in the short timescale of cyclic voltammetry followed by equatorial chloride/water exchange in the longer timescale of macroelectrolysis).

Original languageEnglish
Pages (from-to)2347-2351
Number of pages5
JournalJournal of the Chemical Society. Dalton Transactions
Volume4
Issue number15
DOIs
Publication statusPublished - 26 Jul 2004

Keywords

  • Bioinorganic chemistry
  • Electrohemistry, spectroelectrochemistry
  • Redox/potential/reactions
  • Ruthenium

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