Anti-Helicobacter pylori agents endowed with H2-antagonist properties

Giovanni Sorba; Massimo Bertinaria; Antonella Di Stilo; Alberto Gasco; Maria M. Scaltrito; Maria I. Brenciaglia; Francesco Dubini

doi:10.1016/S0960-894X(00)00671-5

Anti-Helicobacter pylori agents endowed with H₂-antagonist properties

Giovanni Sorba
, Massimo Bertinaria
, Antonella Di Stilo
, Alberto Gasco
, Maria M. Scaltrito
, Maria I. Brenciaglia
, Francesco Dubini

Research output: Contribution to journal › Article › peer-review

Abstract

New anti-Helicobacter pylori (H. pylori) agents endowed with H₂-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H₂-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.

Original language	English
Pages (from-to)	403-406
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/S0960-894X(00)00671-5
Publication status	Published - 12 Feb 2001
Externally published	Yes

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10.1016/S0960-894X(00)00671-5

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title = "Anti-Helicobacter pylori agents endowed with H2-antagonist properties",

abstract = "New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.",

author = "Giovanni Sorba and Massimo Bertinaria and \{Di Stilo\}, Antonella and Alberto Gasco and Scaltrito, \{Maria M.\} and Brenciaglia, \{Maria I.\} and Francesco Dubini",

note = "Funding Information: This work was supported by a grant from MURST, Studi e Ricerche Finalizzate 40\%, Roma. ",

year = "2001",

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doi = "10.1016/S0960-894X(00)00671-5",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - Anti-Helicobacter pylori agents endowed with H2-antagonist properties

AU - Sorba, Giovanni

AU - Bertinaria, Massimo

AU - Di Stilo, Antonella

AU - Gasco, Alberto

AU - Scaltrito, Maria M.

AU - Brenciaglia, Maria I.

AU - Dubini, Francesco

N1 - Funding Information: This work was supported by a grant from MURST, Studi e Ricerche Finalizzate 40%, Roma.

PY - 2001/2/12

Y1 - 2001/2/12

N2 - New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.

AB - New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.

UR - https://www.scopus.com/pages/publications/0035847701

U2 - 10.1016/S0960-894X(00)00671-5

DO - 10.1016/S0960-894X(00)00671-5

M3 - Article

SN - 0960-894X

VL - 11

SP - 403

EP - 406

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 3

ER -

Anti-Helicobacter pylori agents endowed with H₂-antagonist properties

Abstract

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