Angiotensin II vascular receptors in fetal and neonatal rats

Pietro Ghiani, Bianca M. Uva, Alberta Mandich, Maria Angela Masini

Research output: Contribution to journalArticlepeer-review

Abstract

Specific binding sites for angiotensin II in aorta and renal arteries have been studied in rat fetuses (18th day of pregnancy) and 1‐day‐old newborn rats by binding studies in arterial membranes using [125I] ileu‐5‐angiotensin II. One type of angiotensin receptor was found both in fetuses and in the newborns; the capacity of this (RT) decreased immediately after birth (from 0·06 ± 0·01 nM to 0·02 ± 0·005 nM; ± SEM) and the affinity (Kd) increased at birth (from 3·5 ± 0·6 nM to 19·5 ± 1·2 nM; ± SEM). Localization of the specific binding sites was studied by autoradiography on arteries from fetal and newborn rats either perfused with iodinated angiotensin II by cannulation of the aorta or in vitro on cryostat sections incubated with the radioactive angiotensin II. Both in fetuses and in the newborn the binding sites were located in the tunica media of the arteries.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalCell Biochemistry and Function
Volume6
Issue number4
DOIs
Publication statusPublished - Oct 1988
Externally publishedYes

Keywords

  • Angiotensin receptors
  • fetal vascular receptors

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