Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study

Perry T.C. van Doormaal; Nicola Ticozzi; Cinzia Gellera; Antonia Ratti; Franco Taroni; Adriano Chiò; Andrea Calvo; Gabriele Mora; Gabriella Restagno; Bryan J. Traynor; Anna Birve; Robin Lemmens; Michael A. van Es; Christiaan G.J. Saris; Hylke M. Blauw; Paul W.J. van Vught; Ewout J.N. Groen; Lucia Corrado; Letizia Mazzini; Roberto Del Bo; Stefania Corti; Stefan Waibel; Thomas Meyer; Albert C. Ludolph; An Goris; Philip van Damme; Wim Robberecht; Aleksey Shatunov; Isabella Fogh; Peter M. Andersen; Sandra D'Alfonso; Orla Hardiman; Simon Cronin; Dan Rujescu; Ammar Al-Chalabi; John E. Landers; Vincenzo Silani; Leonard H. van den Berg; Jan H. Veldink

doi:10.1016/j.neurobiolaging.2014.04.014

Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study

Perry T.C. van Doormaal
, Nicola Ticozzi
, Cinzia Gellera
, Antonia Ratti
, Franco Taroni
, Adriano Chiò
, Andrea Calvo
, Gabriele Mora
, Gabriella Restagno
, Bryan J. Traynor
, Anna Birve
, Robin Lemmens
, Michael A. van Es
, Christiaan G.J. Saris
, Hylke M. Blauw
, Paul W.J. van Vught
, Ewout J.N. Groen
, Lucia Corrado
, Letizia Mazzini
, Roberto Del Bo

Stefania Corti, Stefan Waibel, Thomas Meyer, Albert C. Ludolph, An Goris, Philip van Damme, Wim Robberecht, Aleksey Shatunov, Isabella Fogh, Peter M. Andersen, Sandra D'Alfonso, Orla Hardiman, Simon Cronin, Dan Rujescu, Ammar Al-Chalabi, John E. Landers, Vincenzo Silani, Leonard H. van den Berg, Jan H. Veldink

Department of Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.

Original language	English
Pages (from-to)	2420.e13-2420.e14
Journal	Neurobiology of Aging
Volume	35
Issue number	10
DOIs	https://doi.org/10.1016/j.neurobiolaging.2014.04.014
Publication status	Published - Oct 2014

Keywords

Amyotrophic lateral sclerosis
Genome-wide association study
KIFAP3
Kinesin-associated protein 3 gene

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10.1016/j.neurobiolaging.2014.04.014

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van Doormaal, P. T. C., Ticozzi, N., Gellera, C., Ratti, A., Taroni, F., Chiò, A., Calvo, A., Mora, G., Restagno, G., Traynor, B. J., Birve, A., Lemmens, R., van Es, M. A., Saris, C. G. J., Blauw, H. M., van Vught, P. W. J., Groen, E. J. N., Corrado, L., Mazzini, L., ... Veldink, J. H. (2014). Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study. Neurobiology of Aging, 35(10), 2420.e13-2420.e14. https://doi.org/10.1016/j.neurobiolaging.2014.04.014

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title = "Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study",

abstract = "Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.",

keywords = "Amyotrophic lateral sclerosis, Genome-wide association study, KIFAP3, Kinesin-associated protein 3 gene",

author = "\{van Doormaal\}, \{Perry T.C.\} and Nicola Ticozzi and Cinzia Gellera and Antonia Ratti and Franco Taroni and Adriano Chi{\`o} and Andrea Calvo and Gabriele Mora and Gabriella Restagno and Traynor, \{Bryan J.\} and Anna Birve and Robin Lemmens and \{van Es\}, \{Michael A.\} and Saris, \{Christiaan G.J.\} and Blauw, \{Hylke M.\} and \{van Vught\}, \{Paul W.J.\} and Groen, \{Ewout J.N.\} and Lucia Corrado and Letizia Mazzini and \{Del Bo\}, Roberto and Stefania Corti and Stefan Waibel and Thomas Meyer and Ludolph, \{Albert C.\} and An Goris and \{van Damme\}, Philip and Wim Robberecht and Aleksey Shatunov and Isabella Fogh and Andersen, \{Peter M.\} and Sandra D'Alfonso and Orla Hardiman and Simon Cronin and Dan Rujescu and Ammar Al-Chalabi and Landers, \{John E.\} and Vincenzo Silani and \{van den Berg\}, \{Leonard H.\} and Veldink, \{Jan H.\}",

year = "2014",

month = oct,

doi = "10.1016/j.neurobiolaging.2014.04.014",

language = "English",

volume = "35",

pages = "2420.e13--2420.e14",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier Inc.",

number = "10",

}

van Doormaal, PTC, Ticozzi, N, Gellera, C, Ratti, A, Taroni, F, Chiò, A, Calvo, A, Mora, G, Restagno, G, Traynor, BJ, Birve, A, Lemmens, R, van Es, MA, Saris, CGJ, Blauw, HM, van Vught, PWJ, Groen, EJN, Corrado, L, Mazzini, L, Del Bo, R, Corti, S, Waibel, S, Meyer, T, Ludolph, AC, Goris, A, van Damme, P, Robberecht, W, Shatunov, A, Fogh, I, Andersen, PM, D'Alfonso, S, Hardiman, O, Cronin, S, Rujescu, D, Al-Chalabi, A, Landers, JE, Silani, V, van den Berg, LH & Veldink, JH 2014, 'Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study', Neurobiology of Aging, vol. 35, no. 10, pp. 2420.e13-2420.e14. https://doi.org/10.1016/j.neurobiolaging.2014.04.014

TY - JOUR

T1 - Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis

T2 - A multicenter survival study

AU - van Doormaal, Perry T.C.

AU - Ticozzi, Nicola

AU - Gellera, Cinzia

AU - Ratti, Antonia

AU - Taroni, Franco

AU - Chiò, Adriano

AU - Calvo, Andrea

AU - Mora, Gabriele

AU - Restagno, Gabriella

AU - Traynor, Bryan J.

AU - Birve, Anna

AU - Lemmens, Robin

AU - van Es, Michael A.

AU - Saris, Christiaan G.J.

AU - Blauw, Hylke M.

AU - van Vught, Paul W.J.

AU - Groen, Ewout J.N.

AU - Corrado, Lucia

AU - Mazzini, Letizia

AU - Del Bo, Roberto

AU - Corti, Stefania

AU - Waibel, Stefan

AU - Meyer, Thomas

AU - Ludolph, Albert C.

AU - Goris, An

AU - van Damme, Philip

AU - Robberecht, Wim

AU - Shatunov, Aleksey

AU - Fogh, Isabella

AU - Andersen, Peter M.

AU - D'Alfonso, Sandra

AU - Hardiman, Orla

AU - Cronin, Simon

AU - Rujescu, Dan

AU - Al-Chalabi, Ammar

AU - Landers, John E.

AU - Silani, Vincenzo

AU - van den Berg, Leonard H.

AU - Veldink, Jan H.

PY - 2014/10

Y1 - 2014/10

N2 - Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.

AB - Sporadic amyotrophic lateral sclerosis is a multifactorial disease of environmental and genetic origin. In a previous large multicenter genome wide study, common genetic variation in the Kinesin-Associated Protein 3 (KIFAP3) gene (rs1541160) was reported to have a significant effect on survival in amyotrophic lateral sclerosis patients. However, this could not be replicated in 3 smaller independent cohorts. We conducted a large multicenter multivariate survival analysis (n= 2362) on the effect of genetic variation in rs1541160. The previously reported beneficial genotype did not show a significant improvement in survival in this patient group.

KW - Amyotrophic lateral sclerosis

KW - Genome-wide association study

KW - KIFAP3

KW - Kinesin-associated protein 3 gene

UR - https://www.scopus.com/pages/publications/84903816507

U2 - 10.1016/j.neurobiolaging.2014.04.014

DO - 10.1016/j.neurobiolaging.2014.04.014

M3 - Article

SN - 0197-4580

VL - 35

SP - 2420.e13-2420.e14

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 10

ER -

Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: A multicenter survival study

Abstract

Keywords

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