TY - JOUR
T1 - Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection
AU - Libra, Massimo
AU - Capello, Daniela
AU - Gloghini, Annunziata
AU - Laura, Pasqualucci
AU - Berra, Eva
AU - Cerri, Michaela
AU - Gasparotto, Daniela
AU - Franca, Stivala
AU - De Re, Valli
AU - Gaidano, Gianluca
AU - Carbone, Antonino
PY - 2005/5
Y1 - 2005/5
N2 - Hepatitis C virus (HCV) and aberrant somatic hypermutation (SHM) have each been suggested to contribute to the development of B-cell non-Hodgkin's lymphoma (NHL). The incidence of PIM-1, PAX-5, RhoH/TTF, and c-MYC mutations in tumour biopsy specimens from 32 HCV-infected B-cell NHL patients was analysed to determine whether the extent of aberrant SHM among these patients differed from that previously reported for HCV-negative B-cell NHL patients. Mutation of PIM-1, PAX-5, RhoH/TTF, and c-MYC was detected in 4 (13%), 5 (16%), 4 (13%), and 4 (13%) of 32 samples, respectively. In HCV-positive B-cell NHL patients, the frequency of aberrant SHM was lower than that already found in HCV-negative B-cell NHL patients. This indicates that, unlike B-cell lymphomas from HCV-negative patients, aberrant SHM may not contribute significantly to malignant transformation in HCV-associated B-cell lymphomas.
AB - Hepatitis C virus (HCV) and aberrant somatic hypermutation (SHM) have each been suggested to contribute to the development of B-cell non-Hodgkin's lymphoma (NHL). The incidence of PIM-1, PAX-5, RhoH/TTF, and c-MYC mutations in tumour biopsy specimens from 32 HCV-infected B-cell NHL patients was analysed to determine whether the extent of aberrant SHM among these patients differed from that previously reported for HCV-negative B-cell NHL patients. Mutation of PIM-1, PAX-5, RhoH/TTF, and c-MYC was detected in 4 (13%), 5 (16%), 4 (13%), and 4 (13%) of 32 samples, respectively. In HCV-positive B-cell NHL patients, the frequency of aberrant SHM was lower than that already found in HCV-negative B-cell NHL patients. This indicates that, unlike B-cell lymphomas from HCV-negative patients, aberrant SHM may not contribute significantly to malignant transformation in HCV-associated B-cell lymphomas.
KW - Aberrant SHM
KW - B-NHL
KW - HCV
UR - http://www.scopus.com/inward/record.url?scp=20944433443&partnerID=8YFLogxK
U2 - 10.1002/path.1754
DO - 10.1002/path.1754
M3 - Article
SN - 0022-3417
VL - 206
SP - 87
EP - 91
JO - Journal of Pathology
JF - Journal of Pathology
IS - 1
ER -
