An Italian population-based case-control study on the association between farming and cancer: Are pesticides a plausible risk factor?

Christian Salerno, Antonella Carcagnì, Sara Sacco, Lucio Antonio Palin, Kris Vanhaecht, Massimiliano Panella, Davide Guido

Research output: Contribution to journalArticlepeer-review

Abstract

This population-based case-control study investigated the association between farming (a proxy for pesticide exposure) and cancer in the Vercelli suburban area (northwest Italy). The residents, aged 25 to 79 years, in the above-mentioned area during the period 2002–2009 were considered. Cases were all the first hospital admissions for cancer. Controls were all the subjects not included in the cases and not excluded from the study. Cases and controls were classified according to whether they occupationally resulted farmers or nonfarmers during the period 1965–2009. Cancer odds ratios (ORs) between farmers and nonfarmers were calculated with generalized linear mixed models adjusted by gender and age. Farmers showed higher odds for all cancers (OR=1.459; p <.001), nonmelanoma skin cancer, colorectal cancer, and breast cancer. The results suggest a plausible association between pesticide exposure and cancer occurrence.

Original languageEnglish
Pages (from-to)147-156
Number of pages10
JournalArchives of Environmental and Occupational Health
Volume71
Issue number3
DOIs
Publication statusPublished - 3 May 2016

Keywords

  • Cancer
  • Italy
  • Province of Vercelli
  • farmers
  • pesticides

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