Aggregation in amphiphilic macrocycle-substituted Gd3+ DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C. Webber; Claudio Cassino; Mauro Botta; Mark Woods

doi:10.1021/ic5028724

Aggregation in amphiphilic macrocycle-substituted Gd³⁺ DOTA-type chelates is affected by the regiochemistry of substitution

Benjamin C. Webber, Claudio Cassino, Mauro Botta, Mark Woods

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Gd³⁺ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

Original language	English
Pages (from-to)	2085-2087
Number of pages	3
Journal	Inorganic Chemistry
Volume	54
Issue number	5
DOIs	https://doi.org/10.1021/ic5028724
Publication status	Published - 2 Mar 2015

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title = "Aggregation in amphiphilic macrocycle-substituted Gd3+ DOTA-type chelates is affected by the regiochemistry of substitution",

abstract = "Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.",

author = "Webber, {Benjamin C.} and Claudio Cassino and Mauro Botta and Mark Woods",

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AU - Webber, Benjamin C.

AU - Cassino, Claudio

AU - Botta, Mauro

AU - Woods, Mark

PY - 2015/3/2

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N2 - Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

AB - Gd3+ chelates of macrocyclic bifunctional chelators (BFCs) can differentiate into two regioisomers: corner and side. These isomers afford different orientations of chelate relative to conjugate. These differences alter the self-assembly, tumbling, and effectiveness as magnetic resonance imaging contrast agents of the two biphenyl conjugate isomers.

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JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 5

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Aggregation in amphiphilic macrocycle-substituted Gd³⁺ DOTA-type chelates is affected by the regiochemistry of substitution

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