Advances and applications of induced pluripotent stem cells

Stefano Pietronave, Maria Prat

Research output: Contribution to journalArticlepeer-review

Abstract

Direct reprogramming of somatic cells into pluripotent cells is an emerging technology for creating patient-specific cells, and potentially opens new scenarios in medical and pharmacological fields. From the discovery of Shinya Yamanaka, who first obtained pluripotent cells from fibroblasts by retrovirus-derived ectopic expression of defined embryonic transcription factors, new methods have been developed to generate safe induced pluripotent stem (iPS) cells without genomic manipulations. This review will focus on the recent advances in iPS technology and their application in pharmacology and medicine.

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalCanadian Journal of Physiology and Pharmacology
Volume90
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Keywords

  • Drug discovery
  • Ips
  • Regenerative medicine
  • Retrovirus

Fingerprint

Dive into the research topics of 'Advances and applications of induced pluripotent stem cells'. Together they form a unique fingerprint.

Cite this