Abstract
Direct reprogramming of somatic cells into pluripotent cells is an emerging technology for creating patient-specific cells, and potentially opens new scenarios in medical and pharmacological fields. From the discovery of Shinya Yamanaka, who first obtained pluripotent cells from fibroblasts by retrovirus-derived ectopic expression of defined embryonic transcription factors, new methods have been developed to generate safe induced pluripotent stem (iPS) cells without genomic manipulations. This review will focus on the recent advances in iPS technology and their application in pharmacology and medicine.
Original language | English |
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Pages (from-to) | 317-325 |
Number of pages | 9 |
Journal | Canadian Journal of Physiology and Pharmacology |
Volume | 90 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2012 |
Externally published | Yes |
Keywords
- Drug discovery
- Ips
- Regenerative medicine
- Retrovirus