Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Giovanni Sorba; Roberta Fruttero; Alberto Gasco; Marco Orsetti

doi:10.1016/0223-5234(87)90058-4

Acyclic analogs of classical H₂-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Giovanni Sorba
, Roberta Fruttero
, Alberto Gasco
, Marco Orsetti

Research output: Contribution to journal › Article › peer-review

Abstract

A few dialkylaminoalkyl substituted ethers and oximes structurally related to classical H₂-antagonists have been synthesized and tested for their in vitro (guinea pig isolated atrium) H₂-antagonistic activities. Some of them are inactive others display activity. Structure-activity relationships are also discussed.

Original language	English
Pages (from-to)	255-259
Number of pages	5
Journal	European Journal of Medicinal Chemistry
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/0223-5234(87)90058-4
Publication status	Published - 1987
Externally published	Yes

Keywords

H-antagonistic activity
ether derivatives
furazan derivatives
oxime derivatives

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10.1016/0223-5234(87)90058-4

Cite this

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title = "Acyclic analogs of classical H2-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes",

abstract = "A few dialkylaminoalkyl substituted ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro (guinea pig isolated atrium) H2-antagonistic activities. Some of them are inactive others display activity. Structure-activity relationships are also discussed.",

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year = "1987",

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AU - Sorba, Giovanni

AU - Fruttero, Roberta

AU - Gasco, Alberto

AU - Orsetti, Marco

PY - 1987

Y1 - 1987

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AB - A few dialkylaminoalkyl substituted ethers and oximes structurally related to classical H2-antagonists have been synthesized and tested for their in vitro (guinea pig isolated atrium) H2-antagonistic activities. Some of them are inactive others display activity. Structure-activity relationships are also discussed.

KW - H-antagonistic activity

KW - ether derivatives

KW - furazan derivatives

KW - oxime derivatives

UR - https://www.scopus.com/pages/publications/0023188085

U2 - 10.1016/0223-5234(87)90058-4

DO - 10.1016/0223-5234(87)90058-4

M3 - Article

SN - 0223-5234

VL - 22

SP - 255

EP - 259

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 3

ER -

Acyclic analogs of classical H₂-antagonists: synthesis and activity of dialkylamioalkyl substituted ethers and oximes

Abstract

Keywords

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