Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella; M. Pennati; A. Bearzatto; R. Leone; D. Colangelo; C. Manzotti; M. G. Daidone; N. Zaffaroni

doi:10.1054/bjoc.2001.1751

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

G. Colella
, M. Pennati
, A. Bearzatto
, R. Leone
, D. Colangelo
, C. Manzotti
, M. G. Daidone
, N. Zaffaroni

Research output: Contribution to journal › Article › peer-review

Abstract

A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

Original language	English
Pages (from-to)	1387-1390
Number of pages	4
Journal	British Journal of Cancer
Volume	84
Issue number	10
DOIs	https://doi.org/10.1054/bjoc.2001.1751
Publication status	Published - 18 May 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BBR 3464
Cisplatin
DNA repair
Ovarian cancer

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10.1054/bjoc.2001.1751

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Colella, G., Pennati, M., Bearzatto, A., Leone, R., Colangelo, D., Manzotti, C., Daidone, M. G., & Zaffaroni, N. (2001). Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions. British Journal of Cancer, 84(10), 1387-1390. https://doi.org/10.1054/bjoc.2001.1751

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title = "Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions",

abstract = "A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.",

keywords = "BBR 3464, Cisplatin, DNA repair, Ovarian cancer",

author = "G. Colella and M. Pennati and A. Bearzatto and R. Leone and D. Colangelo and C. Manzotti and Daidone, \{M. G.\} and N. Zaffaroni",

year = "2001",

month = may,

day = "18",

doi = "10.1054/bjoc.2001.1751",

language = "English",

volume = "84",

pages = "1387--1390",

journal = "British Journal of Cancer",

issn = "0007-0920",

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}

Colella, G, Pennati, M, Bearzatto, A, Leone, R, Colangelo, D, Manzotti, C, Daidone, MG & Zaffaroni, N 2001, 'Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions', British Journal of Cancer, vol. 84, no. 10, pp. 1387-1390. https://doi.org/10.1054/bjoc.2001.1751

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions. / Colella, G.; Pennati, M.; Bearzatto, A. et al.
In: British Journal of Cancer, Vol. 84, No. 10, 18.05.2001, p. 1387-1390.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin

T2 - Cytotoxicity and induction and gene-specific repair of DNA lesions

AU - Colella, G.

AU - Pennati, M.

AU - Bearzatto, A.

AU - Leone, R.

AU - Colangelo, D.

AU - Manzotti, C.

AU - Daidone, M. G.

AU - Zaffaroni, N.

PY - 2001/5/18

Y1 - 2001/5/18

N2 - A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

AB - A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464 Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N-ras) level were observed between BBR 3464 and CDDP.

KW - BBR 3464

KW - Cisplatin

KW - DNA repair

KW - Ovarian cancer

UR - https://www.scopus.com/pages/publications/0035906858

U2 - 10.1054/bjoc.2001.1751

DO - 10.1054/bjoc.2001.1751

M3 - Article

SN - 0007-0920

VL - 84

SP - 1387

EP - 1390

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 10

ER -

Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: Cytotoxicity and induction and gene-specific repair of DNA lesions

Abstract

UN SDGs

Keywords

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