Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Loredana Leone; David Esteban-Gómez; Carlos Platas-Iglesias; Marco Milanesio; Lorenzo Tei

doi:10.1039/c8cc08556k

Accelerating water exchange in Gd^III-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Loredana Leone
, David Esteban-Gómez
, Carlos Platas-Iglesias
, Marco Milanesio
, Lorenzo Tei

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

The Gd^III-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

Original language	English
Pages (from-to)	513-516
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	4
DOIs	https://doi.org/10.1039/c8cc08556k
Publication status	Published - 2019

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title = "Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding",

abstract = "The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.",

author = "Loredana Leone and David Esteban-G{\'o}mez and Carlos Platas-Iglesias and Marco Milanesio and Lorenzo Tei",

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journal = "Chemical Communications",

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AU - Leone, Loredana

AU - Esteban-Gómez, David

AU - Platas-Iglesias, Carlos

AU - Milanesio, Marco

AU - Tei, Lorenzo

PY - 2019

Y1 - 2019

N2 - The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

AB - The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

U2 - 10.1039/c8cc08556k

DO - 10.1039/c8cc08556k

M3 - Article

SN - 1359-7345

VL - 55

SP - 513

EP - 516

JO - Chemical Communications

JF - Chemical Communications

IS - 4

ER -

Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Abstract

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Accelerating water exchange in Gd^III-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding