Accelerating water exchange in GdIII-DO3A-derivatives by favouring the dissociative mechanism through hydrogen bonding

Loredana Leone, David Esteban-Gómez, Carlos Platas-Iglesias, Marco Milanesio, Lorenzo Tei

Research output: Contribution to journalArticlepeer-review

Abstract

The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalChemical Communications
Volume55
Issue number4
DOIs
Publication statusPublished - 2019

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