Abstract
The GdIII-complexes of DO3A-acetophenone and ortho- or para- hydroxyacetophenone ligands have been investigated to assess the effect of the presence of a phenol group on the relaxivity and on the water exchange rate of these potential MRI contrast agents. H-Bonding between the ortho-phenol(ate) groups and the water molecules involved in the dissociative exchange mechanism is shown to speed up the water exchange rate by stabilizing the eight-coordinate transition state.
Original language | English |
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Pages (from-to) | 513-516 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 55 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2019 |