Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi; Eva Berra; Michaela Cerri; Clara Deambrogi; Caterina Barbieri; Silvia Franceschetti; Monia Lunghi; Annarita Conconi; Marco Paulli; Andràs Matolcsy; Laura Pasqualucci; Daniela Capello; Gianluca Gaidano

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Davide Rossi
, Eva Berra
, Michaela Cerri
, Clara Deambrogi
, Caterina Barbieri
, Silvia Franceschetti
, Monia Lunghi
, Annarita Conconi
, Marco Paulli
, Andràs Matolcsy
, Laura Pasqualucci
, Daniela Capello
, Gianluca Gaidano

Department of Translational Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

Original language	English
Pages (from-to)	1405-1409
Number of pages	5
Journal	Haematologica
Volume	91
Issue number	10
Publication status	Published - Oct 2006

Keywords

Aberrant somatic hypermutation
Chronic lymphocytic leukemia
Diffuse large B-cell lymphoma
Follicular lymphoma
Histologic transformation

Cite this

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title = "Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma",

abstract = "The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5\%) cases of FL and 2/9 (22.2\%) cases of B-CLL.",

keywords = "Aberrant somatic hypermutation, Chronic lymphocytic leukemia, Diffuse large B-cell lymphoma, Follicular lymphoma, Histologic transformation",

author = "Davide Rossi and Eva Berra and Michaela Cerri and Clara Deambrogi and Caterina Barbieri and Silvia Franceschetti and Monia Lunghi and Annarita Conconi and Marco Paulli and Andr{\`a}s Matolcsy and Laura Pasqualucci and Daniela Capello and Gianluca Gaidano",

year = "2006",

month = oct,

language = "English",

volume = "91",

pages = "1405--1409",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

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}

TY - JOUR

T1 - Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

AU - Rossi, Davide

AU - Berra, Eva

AU - Cerri, Michaela

AU - Deambrogi, Clara

AU - Barbieri, Caterina

AU - Franceschetti, Silvia

AU - Lunghi, Monia

AU - Conconi, Annarita

AU - Paulli, Marco

AU - Matolcsy, Andràs

AU - Pasqualucci, Laura

AU - Capello, Daniela

AU - Gaidano, Gianluca

PY - 2006/10

Y1 - 2006/10

N2 - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

AB - The molecular mechanisms involved in histologic transformation of follicular lymphoma (FL) and B-chronic lymphocytic leukemia (B-CLL) to diffuse large B-cell lymphoma (DLBCL) are heterogeneous and largely unknown. Here we explored whether aberrant somatic hypermutation, leading to the acquisition of new mutations in PIM-1, PAX-5, RhoH/TTF and c-MYC genes, is involved in transformation from FL or B-CLL to DLBCL. Eighteen sequential pairs of FL/DLBCL (n=9) and B-CLL/DLBCL (n=9) were investigated. Our findings demonstrate that acquisition of novel mutations due to aberrant somatic hypermutation was associated with DLBCL transformation in 5/9 (55.5%) cases of FL and 2/9 (22.2%) cases of B-CLL.

KW - Aberrant somatic hypermutation

KW - Chronic lymphocytic leukemia

KW - Diffuse large B-cell lymphoma

KW - Follicular lymphoma

KW - Histologic transformation

UR - https://www.scopus.com/pages/publications/33750022561

M3 - Article

SN - 0390-6078

VL - 91

SP - 1405

EP - 1409

JO - Haematologica

JF - Haematologica

IS - 10

ER -

Aberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphoma

Abstract

Keywords

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