AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents

Giuseppe Gugliotta; Mauro Botta; Lorenzo Tei

doi:10.1039/c0ob00096e

AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents

Giuseppe Gugliotta
, Mauro Botta
, Lorenzo Tei

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-Gd^III complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.

Original language	English
Pages (from-to)	4569-4574
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	8
Issue number	20
DOIs	https://doi.org/10.1039/c0ob00096e
Publication status	Published - 21 Oct 2010

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abstract = "Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-GdIII complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.",

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AU - Gugliotta, Giuseppe

AU - Botta, Mauro

AU - Tei, Lorenzo

PY - 2010/10/21

Y1 - 2010/10/21

N2 - Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-GdIII complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.

AB - Monomeric and dimeric bifunctional chelates based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) platform bearing arylamino and isothiocyanate groups for conjugation to biomolecules were synthesised. Both systems were used for the preparation of high relaxivity dendrimeric (PAMAM G1) and multimeric octa-GdIII complexes. These systems show enhanced relaxometric properties attributed to the presence of two coordinated, fast exchanging, water molecules (q = 2) on each metal ion and to a rather rigid and compact molecular structure.

UR - https://www.scopus.com/pages/publications/77957663135

U2 - 10.1039/c0ob00096e

DO - 10.1039/c0ob00096e

M3 - Article

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 20

ER -

AAZTA-based bifunctional chelating agents for the synthesis of multimeric/dendrimeric MRI contrast agents

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