A short bout of HFD promotes long-lasting hepatic lipid accumulation

Fausto Chiazza; Tenagne D. Challa; Fabrizio C. Lucchini; Daniel Konrad; Stephan Wueest

doi:10.1080/21623945.2015.1071454

A short bout of HFD promotes long-lasting hepatic lipid accumulation

Fausto Chiazza, Tenagne D. Challa, Fabrizio C. Lucchini, Daniel Konrad, Stephan Wueest

Research output: Contribution to journal › Article › peer-review

Abstract

abstract: A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.

Original language	English
Pages (from-to)	88-92
Number of pages	5
Journal	Adipocyte
Volume	5
Issue number	1
DOIs	https://doi.org/10.1080/21623945.2015.1071454
Publication status	Published - 3 Feb 2016
Externally published	Yes

Keywords

diabetes mellitus
insulin resistance
liver
portal hypothesis
steatosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/21623945.2015.1071454

Cite this

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title = "A short bout of HFD promotes long-lasting hepatic lipid accumulation",

abstract = "abstract: A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.",

keywords = "diabetes mellitus, insulin resistance, liver, portal hypothesis, steatosis",

author = "Fausto Chiazza and Challa, {Tenagne D.} and Lucchini, {Fabrizio C.} and Daniel Konrad and Stephan Wueest",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor and Francis Group, LLC.",

year = "2016",

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doi = "10.1080/21623945.2015.1071454",

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T1 - A short bout of HFD promotes long-lasting hepatic lipid accumulation

AU - Chiazza, Fausto

AU - Challa, Tenagne D.

AU - Lucchini, Fabrizio C.

AU - Konrad, Daniel

AU - Wueest, Stephan

PY - 2016/2/3

Y1 - 2016/2/3

N2 - abstract: A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.

AB - abstract: A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.

KW - diabetes mellitus

KW - insulin resistance

KW - liver

KW - portal hypothesis

KW - steatosis

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DO - 10.1080/21623945.2015.1071454

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A short bout of HFD promotes long-lasting hepatic lipid accumulation

Abstract

Keywords

UN SDGs

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