A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)

Claudio Campagnuolo; Ernesto Fattorusso; Francesca Petrucci; Orazio Taglialatela-Scafati; Giovanni Appendino; Nieves Marquez; Eduardo Muñoz

doi:10.1016/j.bmc.2005.04.025

A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)

Claudio Campagnuolo
, Ernesto Fattorusso
, Francesca Petrucci
, Orazio Taglialatela-Scafati
, Giovanni Appendino
, Nieves Marquez
, Eduardo Muñoz

Research output: Contribution to journal › Article › peer-review

Abstract

Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-κB by tumor necrosis factor-α in T cells.

Original language	English
Pages (from-to)	4238-4242
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	13
DOIs	https://doi.org/10.1016/j.bmc.2005.04.025
Publication status	Published - 1 Jul 2005
Externally published	Yes

Keywords

Cascarilla
Diterpenoids
NF-κB inhibition
Prenylbisabolane

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10.1016/j.bmc.2005.04.025

Cite this

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title = "A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)",

abstract = "Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-κB by tumor necrosis factor-α in T cells.",

keywords = "Cascarilla, Diterpenoids, NF-κB inhibition, Prenylbisabolane",

author = "Claudio Campagnuolo and Ernesto Fattorusso and Francesca Petrucci and Orazio Taglialatela-Scafati and Giovanni Appendino and Nieves Marquez and Eduardo Mu{\~n}oz",

note = "Funding Information: This work was supported by MIUR (Progetto Sostanze Naturali ed Analoghi Sintetici ad Attivit{\`a} Antitumorale). Mass and NMR spectra were recorded at the “Centro di Ricerca Interdipartimentale di Analisi Strumentale” of the University of Naples {\textquoteleft}Federico II{\textquoteright}. The assistance of the staff is gratefully acknowledged. E.M. was supported by the Spanish MCyT grant SAF2001-0037-C04-02.",

year = "2005",

month = jul,

day = "1",

doi = "10.1016/j.bmc.2005.04.025",

language = "English",

volume = "13",

pages = "4238--4242",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd.",

number = "13",

}

TY - JOUR

T1 - A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)

AU - Campagnuolo, Claudio

AU - Fattorusso, Ernesto

AU - Petrucci, Francesca

AU - Taglialatela-Scafati, Orazio

AU - Appendino, Giovanni

AU - Marquez, Nieves

AU - Muñoz, Eduardo

N1 - Funding Information: This work was supported by MIUR (Progetto Sostanze Naturali ed Analoghi Sintetici ad Attività Antitumorale). Mass and NMR spectra were recorded at the “Centro di Ricerca Interdipartimentale di Analisi Strumentale” of the University of Naples ‘Federico II’. The assistance of the staff is gratefully acknowledged. E.M. was supported by the Spanish MCyT grant SAF2001-0037-C04-02.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-κB by tumor necrosis factor-α in T cells.

AB - Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-κB by tumor necrosis factor-α in T cells.

KW - Cascarilla

KW - Diterpenoids

KW - NF-κB inhibition

KW - Prenylbisabolane

UR - https://www.scopus.com/pages/publications/20344407548

U2 - 10.1016/j.bmc.2005.04.025

DO - 10.1016/j.bmc.2005.04.025

M3 - Article

SN - 0968-0896

VL - 13

SP - 4238

EP - 4242

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 13

ER -

A prenylbisabolane with NF-κB inhibiting properties from Cascarilla (Croton eluteria)

Abstract

Keywords

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