A Practical Synthesis of 1,4,7,10-Tetraazacyclododecane, a Pivotal Precursor for MRI Contrast Agents

M. FERRARI; Giovanni Battista GIOVENZANA; G. PALMISANO; M. SISTI

doi:10.1080/00397910008087287

A Practical Synthesis of 1,4,7,10-Tetraazacyclododecane, a Pivotal Precursor for MRI Contrast Agents

M. FERRARI, Giovanni Battista GIOVENZANA, G. PALMISANO, M. SISTI

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A practical preparation of the versatile macrocycle 1,4,7,10-tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.

Original language	English
Pages (from-to)	15-21
Number of pages	7
Journal	Synthetic Communications
Volume	30
Issue number	1
DOIs	https://doi.org/10.1080/00397910008087287
Publication status	Published - 2000

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10.1080/00397910008087287

http://hdl.handle.net/11579/9650

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title = "A Practical Synthesis of 1,4,7,10-Tetraazacyclododecane, a Pivotal Precursor for MRI Contrast Agents",

abstract = "A practical preparation of the versatile macrocycle 1,4,7,10-tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.",

author = "M. FERRARI and GIOVENZANA, \{Giovanni Battista\} and G. PALMISANO and M. SISTI",

note = "Funding Information: This work was supported by CNR (Rome) through ccProgetto Finaliuato Biotecnologiea. Bracco SPA (Milan, Italy) is gratefully acknowledged for instructive discussions.",

year = "2000",

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journal = "Synthetic Communications",

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T1 - A Practical Synthesis of 1,4,7,10-Tetraazacyclododecane, a Pivotal Precursor for MRI Contrast Agents

AU - FERRARI, M.

AU - GIOVENZANA, Giovanni Battista

AU - PALMISANO, G.

AU - SISTI, M.

N1 - Funding Information: This work was supported by CNR (Rome) through ccProgetto Finaliuato Biotecnologiea. Bracco SPA (Milan, Italy) is gratefully acknowledged for instructive discussions.

PY - 2000

Y1 - 2000

N2 - A practical preparation of the versatile macrocycle 1,4,7,10-tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.

AB - A practical preparation of the versatile macrocycle 1,4,7,10-tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.

UR - https://iris.uniupo.it/handle/11579/9650

U2 - 10.1080/00397910008087287

DO - 10.1080/00397910008087287

M3 - Article

SN - 0039-7911

VL - 30

SP - 15

EP - 21

JO - Synthetic Communications

JF - Synthetic Communications

IS - 1

ER -

A Practical Synthesis of 1,4,7,10-Tetraazacyclododecane, a Pivotal Precursor for MRI Contrast Agents

Abstract

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