A Novel Short Convergent Entry into Himbacine Derivatives

Gunther Van Cauwenberge; Ling Jie Gao; Dirk Van Haver; Marco Milanesio; Davide Viterbo; Pierre J. De Clercq

doi:10.1021/ol025801g

A Novel Short Convergent Entry into Himbacine Derivatives

Gunther Van Cauwenberge
, Ling Jie Gao
, Dirk Van Haver
, Marco Milanesio
, Davide Viterbo
, Pierre J. De Clercq

Department of Science and Technological Innovation

Research output: Contribution to journal › Article › peer-review

Abstract

(matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M₂ selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

Original language	English
Pages (from-to)	1579-1582
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	9
DOIs	https://doi.org/10.1021/ol025801g
Publication status	Published - 2 May 2002

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10.1021/ol025801g

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title = "A Novel Short Convergent Entry into Himbacine Derivatives",

abstract = "(matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.",

author = "\{Van Cauwenberge\}, Gunther and Gao, \{Ling Jie\} and \{Van Haver\}, Dirk and Marco Milanesio and Davide Viterbo and \{De Clercq\}, \{Pierre J.\}",

year = "2002",

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doi = "10.1021/ol025801g",

language = "English",

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T1 - A Novel Short Convergent Entry into Himbacine Derivatives

AU - Van Cauwenberge, Gunther

AU - Gao, Ling Jie

AU - Van Haver, Dirk

AU - Milanesio, Marco

AU - Viterbo, Davide

AU - De Clercq, Pierre J.

PY - 2002/5/2

Y1 - 2002/5/2

N2 - (matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

AB - (matrix presented) The IMDA reaction of 9 leads with good stereoselectivity to exo-adduct 10b. The functionalized ABC-ring core in 10 is well suited for the convergent synthesis of analogues of himbacine, a naturally occurring M2 selective muscarine receptor antagonist, as illustrated with the further synthesis of the dehydro-derivative 5.

UR - https://www.scopus.com/pages/publications/0037007744

U2 - 10.1021/ol025801g

DO - 10.1021/ol025801g

M3 - Article

SN - 1523-7060

VL - 4

SP - 1579

EP - 1582

JO - Organic Letters

JF - Organic Letters

IS - 9

ER -

A Novel Short Convergent Entry into Himbacine Derivatives

Abstract

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