A novel luminescent bifunctional POSS as a molecular platform for biomedical applications

Francesco Olivero; Filippo Renò; Fabio Carniato; Manuela Rizzi; Mario Cannas; Leonardo Marchese

doi:10.1039/c2dt30218g

A novel luminescent bifunctional POSS as a molecular platform for biomedical applications

Francesco Olivero, Filippo Renò, Fabio Carniato, Manuela Rizzi, Mario Cannas, Leonardo Marchese

Research output: Contribution to journal › Article › peer-review

Abstract

A novel luminescent polyhedral oligomeric silsesquioxane (POSS) containing in the structure a fluorescein derivative molecule and a carboxylic functionality, suitable to anchor different organic compounds (dyes, markers, drugs, contrast agents,...), was successfully synthesized and characterized in this manuscript by a multidisciplinary approach. An emission enhancement of the dye of ca. four times was found after reaction with POSS, rendering this new hybrid compound a promising contrast agent for optical imaging. In vitro tests on tumoral HeLa cells demonstrated that the luminescent POSS (namely POSS-F), here described, is able to be taken up in the cell cytosol by an efficient and selective process. Its high chemical versatility and peculiar properties could render this novel bifunctional POSS a molecular platform for biomedical applications.

Original language	English
Pages (from-to)	7467-7473
Number of pages	7
Journal	Dalton Transactions
Volume	41
Issue number	25
DOIs	https://doi.org/10.1039/c2dt30218g
Publication status	Published - 7 Jul 2012

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abstract = "A novel luminescent polyhedral oligomeric silsesquioxane (POSS) containing in the structure a fluorescein derivative molecule and a carboxylic functionality, suitable to anchor different organic compounds (dyes, markers, drugs, contrast agents,...), was successfully synthesized and characterized in this manuscript by a multidisciplinary approach. An emission enhancement of the dye of ca. four times was found after reaction with POSS, rendering this new hybrid compound a promising contrast agent for optical imaging. In vitro tests on tumoral HeLa cells demonstrated that the luminescent POSS (namely POSS-F), here described, is able to be taken up in the cell cytosol by an efficient and selective process. Its high chemical versatility and peculiar properties could render this novel bifunctional POSS a molecular platform for biomedical applications.",

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T1 - A novel luminescent bifunctional POSS as a molecular platform for biomedical applications

AU - Olivero, Francesco

AU - Renò, Filippo

AU - Carniato, Fabio

AU - Rizzi, Manuela

AU - Cannas, Mario

AU - Marchese, Leonardo

PY - 2012/7/7

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AB - A novel luminescent polyhedral oligomeric silsesquioxane (POSS) containing in the structure a fluorescein derivative molecule and a carboxylic functionality, suitable to anchor different organic compounds (dyes, markers, drugs, contrast agents,...), was successfully synthesized and characterized in this manuscript by a multidisciplinary approach. An emission enhancement of the dye of ca. four times was found after reaction with POSS, rendering this new hybrid compound a promising contrast agent for optical imaging. In vitro tests on tumoral HeLa cells demonstrated that the luminescent POSS (namely POSS-F), here described, is able to be taken up in the cell cytosol by an efficient and selective process. Its high chemical versatility and peculiar properties could render this novel bifunctional POSS a molecular platform for biomedical applications.

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A novel luminescent bifunctional POSS as a molecular platform for biomedical applications

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