A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia

Sverre Heim; Gian‐Carlo ‐C Avanzi; Rolf Billstroum; Ulf Kristoffersson; Nils Mandahl; Albert N. Bekassy; Stanislaw Garwicz; Thomas Wiebe; Loigi Pegoraro; Michele Falda; Luigi Resegotti; Felix Mitelman

doi:10.1111/j.1365-2141.1987.tb06917.x

A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia

Sverre Heim, Gian‐Carlo ‐C Avanzi, Rolf Billstroum, Ulf Kristoffersson, Nils Mandahl, Albert N. Bekassy, Stanislaw Garwicz, Thomas Wiebe, Loigi Pegoraro, Michele Falda, Luigi Resegotti, Felix Mitelman

Research output: Contribution to journal › Article › peer-review

Abstract

The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re‐evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.

Original language	English
Pages (from-to)	323-326
Number of pages	4
Journal	British Journal of Haematology
Volume	66
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2141.1987.tb06917.x
Publication status	Published - Jul 1987
Externally published	Yes

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title = "A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia",

abstract = "The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re‐evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.",

author = "Sverre Heim and Avanzi, {Gian‐Carlo ‐C} and Rolf Billstroum and Ulf Kristoffersson and Nils Mandahl and Bekassy, {Albert N.} and Stanislaw Garwicz and Thomas Wiebe and Loigi Pegoraro and Michele Falda and Luigi Resegotti and Felix Mitelman",

year = "1987",

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doi = "10.1111/j.1365-2141.1987.tb06917.x",

language = "English",

volume = "66",

pages = "323--326",

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T1 - A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia

AU - Heim, Sverre

AU - Avanzi, Gian‐Carlo ‐C

AU - Billstroum, Rolf

AU - Kristoffersson, Ulf

AU - Mandahl, Nils

AU - Bekassy, Albert N.

AU - Garwicz, Stanislaw

AU - Wiebe, Thomas

AU - Pegoraro, Loigi

AU - Falda, Michele

AU - Resegotti, Luigi

AU - Mitelman, Felix

PY - 1987/7

Y1 - 1987/7

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AB - The translocation t(8;16) (p11;p13) was found as the sole deviation from the normal karyotype in three patients with acute monocytic leukaemia. The bone marrow morphology was strikingly similar in the two cases where smears were available for re‐evaluation: the leukaemic cells showed signs of differentiation, and active erythrophagocytosis was a particularly conspicuous feature. We suggest that t(8;16) (p11;p13) represents a new consistent abnormality in acute monocytic leukaemia, specifically associated with the differentiated subtype (M5b) and with pronounced phagocytic activity by the leukaemic monocytes.

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U2 - 10.1111/j.1365-2141.1987.tb06917.x

DO - 10.1111/j.1365-2141.1987.tb06917.x

M3 - Article

SN - 0007-1048

VL - 66

SP - 323

EP - 326

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 3

ER -

A new specific chromosomal rearrangement, t(8;16) (p11;p13), in acute monocytic leukaemia

Abstract

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