A new furoxan NO-donor rabeprazole derivative and related compounds

Giovanni SORBA; Ubaldina GALLI; C. CENA; R. FRUTTERO; A. GASCO; G. MORINI; M. ADAMI; G. CORUZZI; M. I. BRENCIAGLIA; F. DUBINI

A new furoxan NO-donor rabeprazole derivative and related compounds

Giovanni SORBA
, Ubaldina GALLI
, C. CENA
, R. FRUTTERO
, A. GASCO
, G. MORINI
, M. ADAMI
, G. CORUZZI
, M. I. BRENCIAGLIA
, F. DUBINI

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

Original language	English
Pages (from-to)	899-903
Number of pages	5
Journal	ChemBioChem
Volume	4
Publication status	Published - 2003

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abstract = "Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.",

author = "Giovanni SORBA and Ubaldina GALLI and C. CENA and R. FRUTTERO and A. GASCO and G. MORINI and M. ADAMI and G. CORUZZI and BRENCIAGLIA, \{M. I.\} and F. DUBINI",

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journal = "ChemBioChem",

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T1 - A new furoxan NO-donor rabeprazole derivative and related compounds

AU - SORBA, Giovanni

AU - GALLI, Ubaldina

AU - CENA, C.

AU - FRUTTERO, R.

AU - GASCO, A.

AU - MORINI, G.

AU - ADAMI, M.

AU - CORUZZI, G.

AU - BRENCIAGLIA, M. I.

AU - DUBINI, F.

PY - 2003

Y1 - 2003

N2 - Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

AB - Stomach pump: Gastric antisecretory and protective activity against damaging agents are shown by the pump inhibitor rabeprazole (1). This compound is also potently active against Helicobacter pylori strains that are resistant to metronidazole. Modification of 1 with a furazan or furoxan group significantly reduced its antisecretory potency but not its efficacy. The furoxan analogue, which can act as an NO donor, has a protective activity comparable to that of the parent molecule.

UR - https://iris.uniupo.it/handle/11579/30408

M3 - Article

SN - 1439-4227

VL - 4

SP - 899

EP - 903

JO - ChemBioChem

JF - ChemBioChem

ER -

A new furoxan NO-donor rabeprazole derivative and related compounds

Abstract

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